Results 71 to 80 of about 108,915 (302)
, 2023 [Background] JAK1 is a signaling molecule downstream of cytokine receptors including IL- 4R alpha. Abrocitinib is an oral JAK1 inhibitor and is a safe and effective FDA approved treatment for adults with moderate-to-severe atopic dermatitis.[Objective ...
Ramsey, Nicole +9 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Immunobiology of Acquired Resistance to Ticks
Frontiers in Immunology, 2020 Ticks are blood-sucking arthropods of great importance in the medical and veterinary fields worldwide. They are considered second only to mosquitos as vectors of pathogenic microorganisms that can cause serious infectious disorders, such as Lyme ...
Hajime Karasuyama +2 more
doaj +1 more source
Associations between lymphocyte and basophil counts.
, 2016 Correlation graphs of (A) basophil and CD8 T cell counts; (B) basophil and CD4 T cell counts; and (C) basophil and B cell counts. The Spearman’s rank correlation was used to assess associations between parameters, with rho ≥ 0.25 and p values < 0.05 ...
David Guwatudde (303040) +12 more
core +1 more source
Basophil-derived interleukin-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy [PDF]
, 2018 BACKGROUND: Exaggerated thymic stromal lymphopoietin (TSLP) production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies.
Müller, Christoph +17 more
core +1 more source
Cytoflow: User‐Friendly Python Software for Computational Flow Cytometry
Cytometry Part A, EarlyView.ABSTRACT Modern flow cytometry experiments routinely measure 18 or more fluorescent markers across many samples, patients, and tissues. As these experiments' complexity increases, manual gating becomes unacceptably inefficient and can introduce operator‐to‐operator variation. Computational cytometry algorithms such as unsupervised clustering, automated
Leah Teague
wiley +1 more source
Increased level of basophil CD203c expression predicts severe chronic urticaria. [PDF]
, 2014 Increased FcepsilonR1alpha expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c expression
Shin, YS +5 more
core +1 more source
Cytometry Part A, EarlyView.ABSTRACT Peripheral blood mononuclear cells (PBMCs) are commonly used for immune profiling in clinical research, but their isolation and cryopreservation present logistical challenges, particularly in settings with limited access to research facilities. To address this, we implemented a whole blood fixation protocol to preserve surface protein epitopes
Vaishnavi Parthasarathy +8 more
wiley +1 more source
SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response
Frontiers in Immunology, 2019 Binding of antigen to IgE-high affinity FcεRI complexes on mast cells and basophils results in the release of preformed mediators such as histamine and de novo synthesis of cytokines causing allergic reactions.
Namit Sharma +12 more
doaj +1 more source
Basophil activation test in allergic rhinitis
, 2016 Comment in: Basophil activation test in allergic rhinitis. Authors' reply. [Pol Arch Med Wewn. 2016] | Comment on: Comparison of the basophil activation test versus the nasal provocation test in establishing eligibility for specific immunotherapy.
Chirumbolo, Salvatore +1 more
core +1 more source