Results 61 to 70 of about 114,819 (309)

Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses

Autoimmunity, 2017
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years.
Rachel Ettinger, Jodi L. Karnell, Jill Henault, Santosh K. Panda, Jeffrey M. Riggs, Roland Kolbeck, Miguel A. Sanjuan   +6 more
doaj   +1 more source

Immediate-Type Hypersensitivity to Succinylated Corticosteroids [PDF]

, 2011
Background: Despite their frequent use, systemic corticosteroids have rarely elicited immediate-type reactions. Objective: We report two male patients, aged 26 and 70 years, respectively, with severe immediate-type hypersensitivity secondary to the ...
Przybilla, Bernhard, Raewer, Helen-Caroline, Sieber, Wolfgang, Walker, Annett Isabel   +3 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms [PDF]

, 2016
Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank using high-coverage
Buenrostro, Jason D., Chiarle, Roberto, Esko, Tonu, Fischer, Krista, Gabriel, Stacey B., Guo, Michael H., Hirschhorn, Joel N., Kals, Mart, Kathiresan, Sekar, Lander, Eric S., Magi, Reedik, Metspalu, Andres, Milani, Lili, Mitt, Mario, Nandakumar, Satish K., Natarajan, Pradeep, Palta, Priit, Pärn, Kalle, Salem, Rany M., Sankaran, Vijay G., Ulirsch, Jacob C., Zekavat, Seyedeh M.   +21 more
core   +2 more sources

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Clinical significance of basophil leucocytes in bronchial asthma [PDF]

, 1968
Changes of basophil leucocyte counts of the peripheral blood in bronchial asthma were investigated mainly by our improved method of KOVACS (4). The results are as follows. I) The basophils in bronchial asthma generally show a higher count than in healthy
Kimura, Ikuro, Moritani, Yoshiaki, Nishizaki, Yoshitomo, Tanizaki, Yoshiro   +3 more
core   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Repurposing hydrochlorothiazide (HCTZ) for colorectal cancer: a retrospective and single center study

Frontiers in Pharmacology
BackgroundAnti-hypertensive drugs have been reported to demonstrate anti-inflammatory and anti-angiogenic effects. This study aims to investigate the association between anti-hypertensive drugs and the prognosis of colorectal cancer (CRC) patients ...
Dominic Chi-Chung Foo, Jiaxi Li, Zheng Huang, Siming Sui, Ryan Wai-Yan Sin, Abraham Tak Ka Man, Wai-Lun Law, Lui Ng   +7 more
doaj   +1 more source

E-Cadherin Expression Distinguishes Mouse from Human Hematopoiesis in the Basophil and Erythroid Lineages

Biomolecules, 2022
E-cadherin is a key regulator of epithelial cell–cell adhesion, the loss of which accelerates tumor growth and invasion. E-cadherin is also expressed in hematopoietic cells as well as epithelia.
Rosa A. Krimpenfort, Felix M. Behr, Marja Nieuwland, Iris de Rink, Ron Kerkhoven, Marieke von Lindern, Micha Nethe   +6 more
doaj   +1 more source

Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. [PDF]

, 1983
We have examined the morphology, cytochemistry, and biochemistry of mouse leukocyte subsets by analyzing cloned leukocyte populations specialized to perform different immunologic functions.
Cantor, H, der Simonian, H, Dvorak, AM, Dvorak, HF, Galli, SJ, Goldin, J, Marcum, JA, Monahan, RA, Nabel, G, Pyne, K, Rosenberg, RD   +10 more
core