Results 41 to 50 of about 108,915 (302)

The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils

Frontiers in Immunology, 2019
Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage ...
Christophe Pellefigues, Palak Mehta, Melanie Sarah Prout, Karmella Naidoo, Bibek Yumnam, Jodie Chandler, Sally Chappell, Kara Filbey, Mali Camberis, Graham Le Gros   +9 more
doaj   +1 more source

Contribution of basophils to cutaneous immune reactions and Th2-mediated allergic responses

Frontiers in Immunology, 2015
Basophils are potent effector cells of innate immunity and also play a role in T helper 2 (Th2)-mediated allergic responses. But, although their in vitro functions are well studied, their in vivo functions remain largely unknown.
Atsushi eOtsuka, Kenji eKabashima
doaj   +1 more source

Increased expressions of CD123, CD63, CD203c, and Fc epsilon receptor I on blood leukocytes of allergic asthma

Frontiers in Molecular Biosciences, 2022
Background: Altered basophil identification markers have been discovered to associate with allergic asthma (AA) in recent years. However, little is known about the expression of basophil markers in blood granulocytes.Aim: To parallel test blood basophils
Hua Xie, Hua Xie, Liping Chen, Liping Chen, Huiyun Zhang, Junling Wang, Yanyan Zang, Mengmeng Zhan, Fangqiu Gu, Shunlan Wang, Shaoheng He, Shaoheng He   +11 more
doaj   +1 more source

Adventures with the Basophil

Journal of Investigative Dermatology, 1962
For many, the word adventure conjures travel to distant lands or the exploration of endless outer space. I hope this afternoon to show you that adventure still exists no further away than your fingertips. This is a chronicle of the adventures we have had with a “cinderella” cell in a drop of blood.
openaire   +2 more sources

STAP-2 positively regulates Fc epsilon RI-mediated basophil activation and basophil-dependent allergic inflammatory reactions [PDF]

, 2019
Basophils are an important cell type in the regulation of T(h)2 immune responses. Recently, we revealed that signal-transducing adaptor protein-2 (STAP-2) negatively regulates mast cell activation via Fc epsilon RI.
Sekine, Yuichi, Saitoh, Kodai, Matsuda, Tadashi, Muromoto, Ryuta, Kashiwakura, Jun-ichi, Kitai, Yuichi, Yoshihara, Mari, Yamashita, Shinsuke, Oritani, Kenji, Inui, Kyosuke   +9 more
core   +1 more source

Clinical and Translational Significance of Basophils in Patients with Cancer

Cells, 2022
Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as ...
Jitesh Chauhan, Chara Stavraka, Melanie Grandits, Lais C. G. F. Palhares, Debra H. Josephs, Katie E. Lacy, James Spicer, Heather J. Bax, Sophia N. Karagiannis   +8 more
doaj   +1 more source

Commentary: The Expression of CD123 Can Decrease with Basophil Activation: Implications for the Gating Strategy of the Basophil Activation Test [PDF]

, 2016
Comment on: The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test.
Chirumbolo, Salvatore, Salvatore Chirumbolo   +1 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

From the bench to the clinic: basophils and type 2 epithelial cytokines of thymic stromal lymphopoietin and IL‐33

Clinical & Translational Immunology
Type 2 epithelial cytokines, including thymic stromal lymphopoietin and IL‐33, play central roles in modulation of type 2 immune cells, such as basophils.
Kazushige Obata‐Ninomiya, Tharmalingam Jayaraman, Steven F Ziegler   +2 more
doaj   +1 more source

Applying Surface Plasmon Resonance to Monitor the IgE-Mediated Activation of Human Basophils

Allergology International, 2008
Background: The histamine releasing test which detects histamine released from basophils in vitro is safe, sensitive and widely used for clinical examination in the field of allergy.
Hidenori Suzuki, Yuhki Yanase, Tomoko Tsutsui, Kaori Ishii, Takaaki Hiragun, Michihiro Hide   +5 more
doaj   +1 more source