Results 181 to 190 of about 298,121 (314)

Combined Effects of Regular Aerobic Exercise with Vitamin D Supplementation on Some Apoptosis Indices in the Lung of Rats Exposed to Hydrogen Peroxide

Medical Laboratory Journal, 2019
Background and Objectives: Exercise is a strong physiological stimulus that can affect apoptosis in the lungs by altering a number of extracellular and intracellular signaling pathways.
somayeh ramezani, Maghsoud peeri, Mohammad Ali Azarbaijani, Firoozeh Dehghan   +3 more
doaj  

Activity‐enhancing mutations in an LmrR‐based artificial metalloenzyme destabilize the protein scaffold and alter its conformational plasticity

ChemBioChem, Accepted Article.
Artificial metalloenzymes (ArM) hold great potential for the sustainable catalysis of complex new‐to‐nature reactions. To efficiently improve the catalytic efficacy of ArMs a rational approach is desirable, requiring detailed molecular insight into their conformational landscape.
Adil A. Safeer, Fabrizio Casilli, Wouter Beugelink, Gerard Roelfes, Marc Baldus, Hugo van Ingen   +5 more
wiley   +1 more source

Direct Coumarin Synthesis by Gold Catalyzed Hydroarylation of Alkynoic Acids/Esters

ChemCatChem, EarlyView.
Gold‐catalyzed, direct hydroarylation of alkynoic acids (or esters) with phenols in a small amount of an ionic liquid as solvent and reaction promoter provides an efficient pathway for the one‐pot preparation of coumarins. This synthetic methodology is highly atom efficient, works with <1 mol% gold and the catalytic system is recyclable.
Pietro Bax, Francesco Ravera, Sara Bonfante, Federico Floreani, Andrea Biffis   +4 more
wiley   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

Effect of the Adiantum capillus Veneris Extract on Bax and Bcl2 Apoptotic Markers of Lung Modulation in Trained Rats and Exposed to Hypoxic Stress

Journal of Medicinal Plants, 2017
Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions. Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax ...
M Yadegari, S Riahy, Sh Mirdar, GhR Hamidian, P Mosadegh zavaragh   +4 more
doaj  

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

Effects of concurrent regular aerobic training and garlic extract on cardiac tissue apoptosis markers in aged rats with chronic kidney disease

Journal of Medicinal Plants, 2017
Background: One of the problems due to aging is apoptosis development in various tissues of body. There is some evidence that some drugs induce apoptosis development via oxidative stress.
Zeynab Razavi Majd, Hassan Matin Homaee, Mohammad Ali Azarbayjani, Parvin Farzanegi   +3 more
doaj  

Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation

ESC Heart Failure, EarlyView.
Abstract Aims Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR associated with asymptomatic DMR. Methods and results The study included 1249 asymptomatic patients with moderate or severe DMR from the ...
Christophe Tribouilloy, Yohann Bohbot, Benjamin Essayagh, Giovanni Benfari, Jeroen J. Bax, Thierry Le Tourneau, Yan Topilsky, Clemence Antoine, Dan Rusinaru, Francesco Grigioni, Nina Ajmone Marsan, Aniek van Wijngaarden, Aviram Hochstadt, Jean Christian Roussel, Prabin Thapa, Michelena Hector I, Maurice Enriquez‐Sarano   +16 more
wiley   +1 more source

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

Cancer Communications, EarlyView.
Monika Raab, Balázs Győrffy, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Margareta Kolaric, Matthias Ebert, Khayal Gasimli, Sven Becker, Mourad Sanhaji, Klaus Strebhardt   +10 more
wiley   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source