Results 71 to 80 of about 197,763 (291)

Characterization of Bax Pore Formation Using Fluorescence Techniques

, 2007
Bax is a pro-apoptotic protein believed to permeabilize mitochondria during apoptosis. The mechanism Bax uses is not well understood. In this work, we use fluorescence techniques to shed light on how tBid activates Bax and we examine the topology of the
Lovell, Jonathan
core  

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Combined Effects of Regular Aerobic Exercise with Vitamin D Supplementation on Some Apoptosis Indices in the Lung of Rats Exposed to Hydrogen Peroxide

Medical Laboratory Journal, 2019
Background and Objectives: Exercise is a strong physiological stimulus that can affect apoptosis in the lungs by altering a number of extracellular and intracellular signaling pathways.
somayeh ramezani, Maghsoud peeri, Mohammad Ali Azarbaijani, Firoozeh Dehghan   +3 more
doaj  

Hair growth potential of Salvia plebeia extract and its associated mechanisms

Pharmaceutical Biology, 2020
Context Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.
Guang-Ri Jin, Yi-Lin Zhang, Jonathan Yap, William A. Boisvert, Bog-Hieu Lee   +4 more
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

اثر تمرینات هوازی تداومی و تناوبی بر بیان ژن‌های p53 و Bax و ارتباط آن با استرس اکسیداتیو و مرگ برنامه‌ریزی‌شده سلولی در میوکارد رت‌های مبتلا به انفارکتوس [PDF]

Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
مقدمه: آنفارکتوس میوکارد (MI) یکی از عوامل اصلی مرگ‌ومیر قلبی‌عروقی در جهان است که باعث ایجاد استرس اکسیداتیو و مرگ برنامه‌ریزی‌شده سلولی در بافت قلب می‌شود. این مطالعه تأثیر تمرینات هوازی تداومی (MICT) و تناوبی با شدت بالا (HIIT) را بر بیان ژن‌های p53 و
بهاره مردانی, سعید کشاورز, حسین مجتهدی, لیلا صرامی   +3 more
doaj   +1 more source

Variations sur Cadet Roussel [music] /

, 1920
J.W.C. 3835 (Publisher number). For voice and piano.; Title from list t.p.; "Harmonisées par Arnold Bax, Frank Bridge, Eugène Goossens, John Ireland."; Individual sections within the work by each of the composers are marked with their initials.; Pl. no.:
Bax, Arnold, 1883-1953.
core  

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Bax clustering under apoptotic stress.

, 2012
A) Bax clustering- MCF-7 cells stably expressing GFP-Bax were incubated 6 hours at 37°C with the different conditions and nuclei were stained with Hoechst (100 ng/mL).
Yara Reis (187851), Roland Eils (90), Marti Bernardo-Faura (187859), Benedikt Brors (14082), Thomas Wolf (136760), Anne Hamacher-Brady (177723), Daniela Richter (187864), Nathan R. Brady (51959)   +7 more
core   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source