Results 81 to 90 of about 197,763 (291)

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats

Drug Design, Development and Therapy, 2020
Xiangwei Lv,1,* Pan Lu,1,* Yisen Hu,2 Tongtong Xu1 1Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Cardiology, First Affiliated
Lv X, Lu P, Hu Y, Xu T
doaj  

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

The role of VDAC2 in Bak-, Bax-mediated apoptosis: prospects for use in therapy (a review of literature)

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022
Apoptosis is of great importance for tissue homeostasis and normal embryo- and ontogenesis. Currently great attention is paid to the study of mitochondrial apoptosis that can be realized through the interaction of proteins Bax and Bak, the key ...
A.A. Bolotskaya, V.N. Nikolenko, M.V. San'kova, N.A. Rizaeva   +3 more
doaj   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Effect of Ascorbic Acid on Signaling Pathways of Bcl2 and Bax Genes in AGS Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2020
Introduction: Antioxidants have a great influence on the control of oxidative stress and free radicals; moreover, they cause the expression of apoptosis genes. Accordingly, they have an important role in preventing cancer.
yaser Asefi, Saeid Ghorbian
doaj  

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Effect of 8 Weeks High Intensity Interval Training on the Gene Expression of BAX and BCL-2 in the Left Ventricle of Diabetic Male Wistar Rats

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Regular exercise training with alternating volume fluctuatesblood glucous levels and by regulating signaling in gene expression reduces in myocardial cell apoptosis in diabetic patients.
Alireza Safarnezhad, Maghsoud Peeri, Mohammad Ali Azarbayjani, Maryam Delfan   +3 more
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Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

, 2018
Bibi Kulsoom,1 Tahir Sultan Shamsi,1 Nasir Ali Afsar,2,3 Zahida Memon,4 Nikhat Ahmed,4 Syed Nazrul Hasnain5 1National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan; 2Jinnah Medical and Dental College, Karachi, Pakistan ...
Shamsi TS, Memon Z, Hasnain SN, Afsar NA, Kulsoom B, Ahmed N   +5 more
core  

Effect of the Adiantum capillus Veneris Extract on Bax and Bcl2 Apoptotic Markers of Lung Modulation in Trained Rats and Exposed to Hypoxic Stress

Journal of Medicinal Plants, 2017
Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions. Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax ...
M Yadegari, S Riahy, Sh Mirdar, GhR Hamidian, P Mosadegh zavaragh   +4 more
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