Results 51 to 60 of about 344,945 (269)
Bayesian and non-bayesian evidential updating
Artificial Intelligence, 1987 Orthodox probability theory supposes that (1) we commence with known statistical distributions, (2) these distributions give rise to real- valued probabilities, and (3) these probabilities can be updated by the use of Bayes' theorem. Each of these suppositions has been challenged by recent work in computer science concerning the representation and ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An explanatory differential item functioning (DIF) model by the WinBUG 1.4 [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2007 This study proposed a multilevel logistic regression model to evaluate a source of DIF. The model accounts for the three levels nested structure of the data and combines results of logistic regression analysesto identify level-3 unit characteristic ...
Fred W. Huffer +2 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Probabilistic optimization in the human perceptuo-motor system
Journal of Physical Fitness and Sports Medicine, 2013 Despite the variability of internal and external environments, the human central nervous system (CNS) can generate precise and stable perception and motor behaviors. What mechanism enables this ability?
Shigeki Takeuchi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Frontiers in Environmental Science, 2021 Large compilations of heterogeneous environmental observations are increasingly available as public databases, allowing researchers to test hypotheses across datasets.
Gregory L. Britten +13 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Modeling forest bird population trends at U.S. Army Garrison Pōhakuloa Training Area, Hawaiʻi
Avian Conservation and EcologyHawaiian avifaunal communities have suffered irrevocable harm and significant threats remain for extant species. It is increasingly important to monitor and document bird density to improve our understanding of how remaining species respond to changing ...
Brian T Leo, Lena D Schnell
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Psychologica Belgica, 2021 Mixed results of the impact of transcranial direct current stimulation (tDCS) on working memory have been reported. Contrarily to previous studies who focused mainly on stimulating the dorsolateral prefrontal cortex, we modulated the left intraparietal ...
Romain Dumont +2 more
doaj +1 more source