Biological activity In vitro, absorption, BBB penetration and toxicity of nanoformulation of BT44, a RET agonist with disease-modifying potential for the treatment of neurodegeneration [PDF]
, 2021 Malik Salman Haider +7 more
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Sleep Alters the Velocity of Physiological Brain Pulsations in Humans
Advanced Science, EarlyView.Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy +13 more
wiley +1 more source
Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging
Frontiers in Aging Neuroscience, 2018 Blood-brain barrier (BBB) modeling in vitro is a huge area of research covering study of intercellular communications and development of BBB, establishment of specific properties that provide controlled permeability of the barrier.
Elena D. Osipova +12 more
doaj +1 more source
microRNA152-3p protects against ischemia/reperfusion-induced BBB destruction possibly targeting MAP3K2/JNK/c-Jun pathway [PDF]
, 2022 Fei Li, Fangfang Zhou, Binbin Yang
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DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut
Advanced Science, EarlyView.Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su +16 more
wiley +1 more source
Nature CommunicationsBlood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear.
Sung-Hyun Yoon +14 more
doaj +1 more source
Long-term Administration of CU06-1004 Ameliorates Cerebrovascular Aging and BBB Injury in Aging Mouse Model: A Randomized Control Trial [PDF]
, 2022 Hyejeong Kim +6 more
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Binary sequences which contain no $BBb$ [PDF]
Transactions of the American Mathematical Society, 1980 A (one-sided) sequence or (two-sided) bisequence is irreducible provided it contains no block of the form BBb, where b is the initial symbol of the block B. Gottschalk and Hedlund [Proc. Amer. Math. Soc. 15 (1964), 70-74] proved that the set of irreducible binary bisequences is the Morse minimal set M. Let M+ denote the one-sided Morse minimal set, i.e.
openaire +2 more sources
Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair
Advanced Science, EarlyView.This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz +20 more
wiley +1 more source