Results 131 to 140 of about 272,441 (303)

SONIC HEDGEHOG (SHH) PROMOTES BLOOD-BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE MIDLINE GLIOMA OF THE PONS [PDF]

, 2023
Stacey Line, Babu V. Sajesh, Vinith Yathindranath, Nog H On, Donald W. Miller, Magimairajan Vanan   +5 more
openalex   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Modular Tissue-in-a-CUBE Platform to Model Blood-brain-Barrier (BBB) and Brain Interaction [PDF]

, 2023
Isabel Koh, Masaya HAGIWARA
openalex   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

DETECTION OF LEVOCETIRIZINE INTERACTIONS WITH NSAIDS BY SPECTROPHOTOMETRIC TECHNIQUE

FUUAST Journal of Biology
Levocetirizine, a levorotatory enantiomer of anti-histamine cetirizine, available as hydrochloride and useful in the management of intermittent or persistent allergic rhinitis and hay fever.
SHAFAQUE MEHBOOB, KIRAN RAFIQUE, MEHWISH WAJDI, ASMA WAZIR, NEMAT NAZIR, MALEEHA FARRUKH, SHAGUFTA USMANI, KHWAJA ZAFAR AHMED, AURANGZEB KHAN   +8 more
doaj  

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Hydrogel-based microfluidic model of the blood-brain barrier: progress and future perspectives

Fluids and Barriers of the CNS
The development of brain-targeted delivery systems is significantly hindered by the blood-brain barrier (BBB), which prevents drugs from effectively reaching therapeutic regions in the brain.
Fangyuan Guo, Jialin Chen, Lianyi Wang, Mengqian Li, Qinan Lv, Jun Wang, Weiyong Hong, Gensheng Yang   +7 more
doaj   +1 more source

GL(2, Bbb R) dualities in generalised Z(2) gauge theories and Ising models [PDF]

, 2007
Nelson Yokomizo, Paulo Teotonio-Sobrinho
openalex   +1 more source

Endothelial cell CD36 mediates stroke-induced brain injury via BBB dysfunction and monocyte infiltration in normal and obese conditions [PDF]

, 2023
Il‐Doo Kim, Hyunwoo Ju, Joseph Minkler, Roselyn R. Jiang, Abhilasha Singh, Roopa Sharma, Maria Febbraio, Sunghee Cho   +7 more
openalex   +1 more source