Results 71 to 80 of about 18,005 (233)

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression [PDF]

, 2019
Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a multi-omic approach to examine liver carcinogenesis and regeneration, and find that progressive ...
Shuen, Wai Ho, Ding, Zhaobing, McDonnell, Eoin, Kwok, Royston, Ericksen, Russell E., White, Phillip J., Lee, Philip, Han, Weiping, Toh, Han Chong, Hirschey, Matthew D., Lim, Siew Lan, Vadiveloo, Maya, Radda, George K.   +12 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy. [PDF]

JACC Basic Transl Sci
Dysregulated branched-chain amino acid (BCAA) metabolism occurs in pulmonary arterial hypertension (PAH), but its role in pulmonary vascular disease and resultant hepatopathy remains undefined.
Blake MJ, Hong J, Brownstein A, Rhodes CJ, Swietlik EM, Blake JC, Moon RA, Hartweck LM, Mendelson JB, Prisco SZ, Markowski T, Higgins L, Murray K, Guerrero C, Breuils-Bonnet S, Provencher S, Pepke-Zaba J, Toshner M, Wilkins M, Bonnet S, Prins KW.   +20 more
europepmc   +3 more sources

Gut Enterococcus faecium derived leucic acid mediates the antiobesity effect of dietary fiber

iMeta, EarlyView.
This study identified Enterococcus faecium as a gut bacterium with anti‐obesity activity, which alleviated adipocyte hypertrophy, dyslipidemia, and hepatic steatosis by converting leucine into leucic acid (LEA) to regulate mitochondrial oxidative phosphorylation.
Baifei Hu, Qianru Gao, Junmin Hui, Mengqiong Wang, Haiyan Gao, Kai Li, Junping Zheng, Zhe Dai, Songlin Liu, Hongtao Liu   +9 more
wiley   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation [PDF]

Cancer Discovery, 2019
Abstract Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here, we show that EZH2 and NRASG12D mutations cooperatively induce progression of myeloproliferative ...
Zhimin Gu, Yuxuan Liu, Feng Cai, McKenzie Patrick, Jakub Zmajkovic, Hui Cao, Yuannyu Zhang, Alpaslan Tasdogan, Mingyi Chen, Le Qi, Xin Liu, Kailong Li, Junhua Lyu, Kathryn E. Dickerson, Weina Chen, Min Ni, Matthew E. Merritt, Sean J. Morrison, Radek C. Skoda, Ralph J. DeBerardinis, Jian Xu   +20 more
openaire   +4 more sources

Rli60 mediates Lm’s BCAA partial-auxotrophy.

, 2018
(A) Presentation of maximal OD measurements (600 nm) of WT bacteria and indicated mutants grown in minimal defined medium containing decreasing concentrations of BCAA (800 μM, 80 μM, 20 μM and without a supplement of BCAA).
Anat A. Herskovits (136758), Lior Lobel (136755), Moran Brenner (4952014), Nadejda Sigal (136756), Ilya Borovok (47763)   +4 more
core   +1 more source

BCAA supplementation in mice with diet-induced obesity alters the metabolome without impairing glucose homeostasis

, 2021
Circulating branched chain amino acid (BCAA) levels are elevated in obese humans and genetically obese rodents. However, the relationship of BCAAs to insulin resistance in diet-induced obese mice, a commonly used model to study glucose homeostasis, is ...
Vijayakumar, Archana, Lee, Jennifer, Ilkayeva, Olga, White, Phillip, Lynch, Christopher, Kahn, Barbara, Xu, Yuping, Newgard, Christopher   +7 more
core   +1 more source

Gold‐Modified Mesoporous Carbon Enables Serum Metabolic Fingerprinting for Papillary Thyroid Carcinoma Diagnosis

Small Methods, EarlyView.
A novel MCHS‑Au‑LA substrate is developed for carbon‑gold nanostructure‐initiator mass spectrometry (C‑Au‑NIMS), which acquires metabolic fingerprints of serum samples from papillary thyroid carcinoma (PTC), benign thyroid nodules (BTN), and healthy controls (HC).
Wanwan Yi, Yida Huang, Jiayou Feng, Xiaowen Zhang, Yuheng Zhu, Kun Qian, Chang Lei, Zhongwei Lv, Chengzhong Yu   +8 more
wiley   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source