Results 91 to 100 of about 2,056 (164)

mRNA‐Lipid Nanoparticle‐Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 11, Issue 32, August 27, 2024.
Through a genome‐wide CRISPR/Cas9 knockout screen, tyrosine‐protein phosphatase nonreceptor type 14 (PTPN14) is identified as a key regulator of anoikis resistance in triple‐negative breast cancer (TNBC). Overexpressing PTPN14 inhibits anoikis resistance, tumorigenicity, and metastasis in TNBC cells by dephosphorylating breast cancer antiestrogen ...
Wei Li, Masha Huang, Zhaoping Wu, Yu Zhang, Ying Cai, Juncheng Su, Jia Xia, Fan Yang, Desheng Xiao, Wen Yang, Yingjie Xu, Zhaoqian Liu   +11 more
wiley   +1 more source

Estrogen Inhibits RANKL-stimulated Osteoclastic Differentiation of Human Monocytes through Estrogen and RANKL-regulated Interaction of Estrogen Receptor-α with BCAR1 and Traf6

Experimental Cell Research, 2009
The effects of estrogen on osteoclast survival and differentiation were studied using CD14-selected mononuclear osteoclast precursors from peripheral blood. Estradiol at ~1 nM reduced RANKL-dependent osteoclast differentiation by 40–50%.
L. Robinson, B. Yaroslavskiy, Reed D. Griswold, Eva V. Zadorozny, Lida Guo, I. Tourkova, H. Blair   +6 more
semanticscholar   +1 more source

Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations

BMC Cancer, 2018
Background Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with adverse outcome of prostate cancer patients. The aim of this study was to determine the molecular aberrations associated with CR/IDC in primary prostate cancer, focusing
René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster, Geert J. L. H. van Leenders   +12 more
doaj   +1 more source

NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients [PDF]

, 2017
Altres ajuts: Fundació La Marató TV3 [416/C/2013-2030,100830/31/32]; Josep Carreras Leukemia Research Institute [P/AG 2014]; Spanish Health Research Program [PI12/02321]; Spanish Association Against Cancer (AECC) [to MCC]; and a grant from the Cellex ...
M. Carmen Chillón, Ramon Mangues, Sierra, Jorge, Nomdedéu, Josep, Montserrat Hoyos, Marcos González-Díaz, Céspedes, María Virtudes, Eva Barragán, Conde, M. Isabel Prieto, Mangues, Ramon, Sanz, Miguel Ángel, Brunet, Salut, Marta Llop, Pallarès, Victor, González-Díaz, Marcos, Josep F. Nomdedeu, Chillón, M. Carmen, Hoyos Colell, Montserrat, Isolda Casanova, Victor Pallarès, M. Isabel Prieto Conde, Jorge Sierra, Salut Brunet, Casanova Rigat, Isolda, Universitat Autònoma de Barcelona, María Virtudes Céspedes, Miguel Ángel Sanz, Llop, Marta, Barragán, Eva   +28 more
core   +1 more source

The BCAR1 locus in carotid intima-media thickness and atherosclerosis [PDF]

, 2016
Carotid intima media thickness (IMT) is a marker of subclinical atherosclerosis that can predict cardiovascular events over traditional risk factors. This thesis focused on a chromosome 16 locus associated with IMT and coronary artery disease, in order ...
Boardman-Pretty, FA
core  

Additional file 1: of Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

, 2018
Figure S1. Skin specific deletion of p130Cas/BCAR1 gene. Figure S2. Keratin1 staining. Figure S3. Dot plot quantification of Ki67 and PCNA. Fig. S4 ΔNp63 and YAP expression. Figure S5.
Marianna Sciortino (5926640), Sara Cabodi (114276), Stefania Saoncella (5926628), Vincenzo Calautti (5926643), Matilde Simoni (5926631), Maria del Pilar Camacho Leal (114265), Aurora Dadone (5926637), Paola Defilippi (114275), Dora Natalini (5926634), Beatrice Tassone (5926625), Andrea Costamagna (5926622), Emilia Turco (114274)   +11 more
core   +1 more source

A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer.

PLoS ONE, 2015
Molecular targeted therapies have been the focus of recent clinical trials for the treatment of patients with recurrent epithelial ovarian cancer (EOC). The majority have not fared well as monotherapies for improving survival of these patients.
Harsh B Pathak, Yan Zhou, Geetika Sethi, Jeff Hirst, Russell J Schilder, Erica A Golemis, Andrew K Godwin   +6 more
doaj   +1 more source

A pre-metazoan origin of the CRK gene family and co-opted signaling network. [PDF]

, 2016
CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the origin of their shared functions, we have investigated their evolutionary history.
OKIMOTO, Noriaki, KI, Sewon, KIGAWA, Takanori, KASAI, Takuma, TAIJI, Makoto, SHIGENO-NAKAZAWA, Yoko, PAWLAK, Jana, IMAMOTO, Akira, SATTA, Yoko, YAMAGISHI, Junya, KOSTYANOVSKAYA, Elina, WESTBROOK, Jody, OKADA, Mariko   +12 more
core   +1 more source

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes:rationale and design of the epidemiological studies within the IMI DIRECT Consortium [PDF]

, 2014
Aims/hypothesisThe DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe.
Rauh, S., Jablonka, B, Bernd Jablonka, Teare, Harriet J A, Frost, G.S., Ridderstråle, Martin, Herrgard, S., Hattersley, A, McDonald, T. J., Sanna Herrgård, Franks, Paul W., Bell, J., Cederberg, Henna, Hansen, TH, Andrea Mari, Pedersen, Oluf, Siloaho, Maritta, Mark Walker, Pearson, Ewan; id_orcid, Pearson, Ewan, Heymans, Martijn W., Perry, MH, Hansen, T.H., Rauh, S, Veikko Koivisto, Ridderstråle, Martin,, McDonald, T.J., Brunak, Søren, Cederberg, H., Barnett, A, Heymans, MartijnW., Frost, G, Vestergaard, H., Hattersley, Andrew T., Franks, P.W., Perry, Mandy, Laakso, M., Consortium, Direct, Paul W. Franks, Barnett, A., Heggie, A., Hansen, T., Thorand, Barbara, Heymans, MW, Siloaho, M., null null, Maritta Siloaho, Koivula, RW, Henrik Vestergaard, Hansen, Tue H., Alison Heggie, Lund University., Teare, Harriet J. A., Hansen, Tue H, Ewan Pearson, Ruetten, H, Hansen, T, Ramneek Gupta, Dekker, Jacqueline M, Rutters, Femke, Walker, M, Koopman, Anitra D, Tim J. McDonald, Barnett, Anna, Pearson, E, Koopman, AD, Koivula, R. W., Pearson, E., Koivula, Robert W., Heggie, Alison, McDonald, TJ, Koivula, Robert, Frost, G., Franks, PaulW., Rutters, F., Koopman, A. D., Perry, M.H., Heymans, M.W., Heggie, A, Ruetten, Hartmut, Simone Rauh, DIRECT Consortium (), Dekker, JM, Perry, MandyH., Hattersley, A., Koivula, R.W., Pearson, E. R., Franks, Paul, Herrgård, S, Franks, P. W., Vestergaard, H, Tue H. Hansen, Heymans, M. W., Koopman, AnitraD., Frost, Gary, Markku Laakso, Gary Frost, Gupta, Ramneek, Bell, J, Koopman, Anitra, Herrgård, Sanna, Teare, HJA, Dekker, Jacqueline M., Hattersley, Andrew, Hansen, Tue Haldor, Walker, M., Torben Hansen, Ridderstråle, M, Bell, Jimmy, Thorand, B, Brunak, S., Heymans, Martijn W, Søren Brunak, Laakso, M, Koopman, Anitra D., Koivisto, V., Mari, Andrea, Perry, Mandy H, Ridderstrale, M., Femke Rutters, Brunak, Soren, Pedersen, O., Hansen, Torben, Jacqueline M. Dekker, Perry, M. H., Gupta, R, Mari, A., Barbara Thorand, Teare, H. J. A., Koivisto, V, Mari, A, Dekker, JacquelineM., Koivula, RobertW., Walker, Mark, Oluf Pedersen, Franks, Paul,, Dekker, J.M., Siloaho, M, Ruetten, H., Cederberg, H, Koopman, A.D., Teare, HarrietJ.A., Pedersen, O, Dekker, J. M., Mandy H. Perry, Anitra D. Koopman, Martijn W. Heymans, Anna Barnett, Koivisto, Veikko, Laakso, Markku, Teare, H.J.A., Hansen, T. H., McDonald, TimJ., Henna Cederberg, Rauh, Simone, McDonald, Tim J, Gupta, R., Harriet J. A. Teare, Teare, H.J., Hartmut Ruetten, Jablonka, Bernd, Brunak, S, Bell, J.D., Andrew Hattersley, Franks, PW, Rutters, F, Vestergaard, Henrik, Hansen, T. V. O., Martin Ridderstråle, Robert W. Koivula, Thorand, B., Jablonka, B., Jimmy Bell, Koivula, Robert,, McDonald, Tim J., Perry, Mandy H., McDonald, Timothy J.   +176 more
core   +1 more source

Treatment with SRC inhibitors reverses CAS-induced downregulation of E-cadherin.

, 2013
Immunofluorescence of MCF7 cells expressing vector pcDNA-GFP, pcDNA-GFP-NEDD9, pcDNA-GFP-BCAR1, or pcDNA-GFP-NEDD9 and pcDNA-GFP-BCAR1 (transfected cells shown in green) and treated with vehicle or PP2.
Nadezhda Tikhmyanova (243180), Erica A. Golemis (159379)   +1 more
core   +1 more source