Results 81 to 90 of about 2,056 (164)

Multiple Origins of Sex Chromosomes in Nothobranchius Killifishes

Molecular Ecology, Volume 34, Issue 16, August 2025.
ABSTRACT Sex chromosomes have evolved repeatedly across eukaryotes. The emergence of a sex‐determining (SD) locus is expected to progressively restrict recombination, driving convergent molecular differentiation. However, evidence from taxa like teleost fishes, representing over half of vertebrate species with unmatched diversity in SD systems ...
Monika Hospodářská, Pablo Mora, Anna Chung Voleníková, Ahmed Al‐Rikabi, Marie Altmanová, Sergey A. Simanovsky, Nikolas Tolar, Tomáš Pavlica, Karolína Janečková, Jana Štundlová, Kseniya Bobryshava, Marek Jankásek, Matyáš Hiřman, Thomas Liehr, Martin Reichard, Eugene Yu. Krysanov, Petr Ráb, Christoph Englert, Petr Nguyen, Alexandr Sember   +19 more
wiley   +1 more source

Biophysical properties of intrinsically disordered p130Cas substrate domain--implication in mechanosensing.

PLoS Computational Biology, 2014
Mechanical stretch-induced tyrosine phosphorylation in the proline-rich 306-residue substrate domain (CasSD) of p130Cas (or BCAR1) has eluded an experimentally validated structural understanding.
Kinya Hotta, Soumya Ranganathan, Ruchuan Liu, Fei Wu, Hiroaki Machiyama, Rong Gao, Hiroaki Hirata, Neelesh Soni, Takashi Ohe, Christopher W V Hogue, M S Madhusudhan, Yasuhiro Sawada   +11 more
doaj   +1 more source

Defining short linear motif binding determinants by phage display‐based deep mutational scanning

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Deep mutational scanning (DMS) has emerged as a powerful approach for evaluating the effects of mutations on binding or function. Here, we developed a DMS by phage display protocol to define the specificity determinants of short linear motifs (SLiMs) binding to peptide‐binding domains.
Caroline Benz, Lars Maassen, Leandro Simonetti, Filip Mihalic, Richard Lindqvist, Ifigenia Tsitsa, Aimiliani Konstantinou, Per Jemth, Anna K. Överby, Norman E. Davey, Ylva Ivarsson   +10 more
wiley   +1 more source

Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway. [PDF]

, 2004
INTRODUCTION: Tamoxifen is effective for endocrine treatment of oestrogen receptor-positive breast cancers but ultimately fails due to the development of resistance.
Dorssers, L.C.J. (Lambert), Agthoven, A.J. (Ton) van, Dechering, K.J. (Koen), Smid, M. (Marcel), Veldscholte, J. (Jos), Brinkman, A. (Arend), Veldscholte, Jos, Dechering, KJ, Agthoven, Ton, Dorssers, Lambert, Brinkman, A (Arend), Smid, Marcel   +11 more
core   +2 more sources

Genome‐Wide DNA Methylation Identifies Potential Disease‐Specific Biomarkers and Pathophysiologic Mechanisms in Irritable Bowel Syndrome, Inflammatory Bowel Disease, and Celiac Disease

Neurogastroenterology &Motility, Volume 37, Issue 2, February 2025.
Comprehensive genome‐wide DNA methylation profiling of blood cells in irritable bowel syndrome, inflammatory bowel disease, celiac disease, and healthy controls identifies potential biomarkers associated with disease‐specific pathways and shows promise as a biomarker for differential diagnosis of gastrointestinal disorders.
Swapna Mahurkar‐Joshi, Mike Thompson, Elizza Villarruel, James D. Lewis, Lisa D. Lin, Mary Farid, Hamed Nayeb‐Hashemi, Tina Storage, Guy A. Weiss, Berkeley N. Limketkai, Jenny S. Sauk, Emeran A. Mayer, Lin Chang   +12 more
wiley   +1 more source

Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.

, 2021
AIM: The adapter protein p130Cas, encoded by the Bcar1 gene, is a key regulator of cell movement, adhesion, and cell cycle control in diverse cell types.
Tam, Y, Scambler, P, Frankel, P, Evans, I, Walker-Samuel, S, Zachary, I, Walsh, C, Mahmoud, M, Wisniewski, L   +8 more
core  

Quercetin Modulates the p53 Signaling Pathway to Induce Apoptosis: Combating Vemurafenib Resistance in Melanoma

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Background: Melanoma is an aggressive skin cancer with a high potential for developing resistance to targeted therapies. One such therapy, vemurafenib, specifically inhibits the B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) V600E mutation, a key driver of melanoma progression. However, acquired resistance to vemurafenib remains a major challenge,
Ching Wen Huang, Gong Yau Chu, Chieh Chen Huang, Chung Hua Hsu, Muhammad Iqhrammullah   +4 more
wiley   +1 more source

Genetics of anomalies of the kidney and urinary tract with congenital heart disease: A review

Clinical Genetics, Volume 106, Issue 6, Page 667-678, December 2024.
Anomalies of the kidney and heart are the most commonly recognized congenital defects and constitute a major cause of morbidity in children. For example, STRING protein‐protein interaction network for the hepatocyte nuclear factor 1‐beta (HNF1B) gene with first‐tier functional interactions involving detection of glucose and exocrine pancreas ...
Amin J. Barakat, Merlin G. Butler
wiley   +1 more source

شناسایی مناطق ژنومی تحت انتخاب مثبت کنترل کننده صفات ساختاری بدن در نژادهای مختلف بز [PDF]

تحقیقات تولیدات دامی
هدف از این پژوهش، شناسایی مناطق ژنومی تحت انتخاب مرتبط با صفات ساختاری بدن در نژادهای مختلف بز بود. بدین ­منظور، از اطلاعات ژنوتیپی 728 رأس بزهای غیرخویشاوند متعلق به چهار نژاد مختلف تعیین ژنوتیپ شده با آرایه­های­50K ­ استفاده شد. جهت شناسایی نواحی ژنومی
حسین محمّدی
doaj   +1 more source

Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity‐associated gene network in myeloid cells

Immunology &Cell Biology, Volume 102, Issue 8, Page 702-720, September 2024.
We hypothesized that a complex genetic phenotype such as multiple sclerosis (MS) could be driven by the coordinated expression of genes controlled by transcriptional regulatory networks. Applying a weighted gene coexpression network analysis (WGCNA) on five purified leukocyte subsets, a cytotoxicity‐associated gene network in myeloid cells was ...
Margaret A Jordan, Melissa M Gresle, Adrian T Gemiarto, Dragana Stanley, Letitia D Smith, Louise Laverick, Tim Spelman, Jim Stankovich, Annie ML Willson, Xuyen T Dinh, Laura Johnson, Kylie Robertson, Christopher AR Reid, Judith Field, Helmut Butzkueven, Alan G Baxter   +15 more
wiley   +1 more source