Results 71 to 80 of about 2,056 (164)
Human Mutation, Volume 2026, Issue 1, 2026.Recent medical advances have significantly improved the life expectancy of individuals with congenital heart disease (CHD); however, these children remain at increased risk of co‐occurring neurodevelopmental disorders (NDD), such as attention‐deficit/hyperactivity disorder and autism spectrum disorder. Although prenatal environmental factors, including
Jamie-Lee M. Thompson +19 more
wiley +1 more source
Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion
Scientific Reports, 2017 ErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers
Marianna Sciortino +10 more
doaj +1 more source
HLA, Volume 106, Issue 6, December 2025.ABSTRACT The autoimmune regulator (AIRE) gene deficiency in humans causes the autoimmune polyglandular syndrome type 1 (APS‐1). AIRE contributes to self‐tolerance and prevents autoimmunity via the regulation of tissue‐restricted antigen (TRA) expression in medullary thymic epithelial cells (mTECs).
A. C. Monteleone‐Cassiano +8 more
wiley +1 more source
NEDD9 and BCAR1 Negatively Regulate E-Cadherin Membrane Localization, and Promote E-Cadherin Degradation [PDF]
, 2012 The Cas scaffolding proteins (NEDD9/HEF1/CAS-L, BCAR1/p130Cas, EFSSIN, and HEPL/CASS4) regulate cell migration, division and survival, and are often deregulated in cancer. High BCAR1 expression is linked to poor prognosis in breast cancer patients, while
Golemis| +2 more
core +1 more source
Advanced Science, Volume 12, Issue 44, November 27, 2025.Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen +9 more
wiley +1 more source
Ecology and Evolution, Volume 15, Issue 10, October 2025.This study explores the use of invertebrate‐derived DNA (iDNA) from haematophagous leeches to assess vertebrate biodiversity in the tropical rainforests of Indonesia. By applying Sanger sequencing with five primer sets, we detected 17 unique vertebrate taxa, including the rare Leptobrachium waysepuntiense, demonstrating the potential of iDNA as a ...
Ardika Dani Irawan, Katsuyuki Eguchi
wiley +1 more source
Cell Death Discovery, 2021 Current therapeutic approaches have met limited clinical success for glioblastoma multiforme (GBM). Since GBM harbors genomic alterations in cyclin-dependent kinases (CDKs), targeting these structures with specific inhibitors (CDKis) is promising.
Christin Riess +6 more
doaj +1 more source
Gene Expression Patterns, 2015 Primitive hematopoiesis generates red blood cells that deliver oxygen to the developing embryo. Mesodermal cells commit to a primitive blood cell fate during gastrulation and, in order to do so the mesoderm must receive non-cell autonomous signals ...
Y. Green, Sunjong Kwon, J. Christian
semanticscholar +1 more source
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment
Aging Cell, Volume 24, Issue 10, October 2025.Local growth hormone (GH) is expressed and secreted by senescent cells in the aging human colon. GH triggers epithelial‐to‐mesenchymal transition and activates colon cell motility by regulating extracellular matrix proteins, inducing cytoskeleton rearrangement and altering cell motility protein phosphorylation.
Vera Chesnokova +8 more
wiley +1 more source
Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang +4 more
wiley +1 more source