Results 51 to 60 of about 2,056 (164)

Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing

Frontiers in Immunology, 2021
Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene.
Amund Holte Berger, Amund Holte Berger, Amund Holte Berger, Eirik Bratland, Eirik Bratland, Eirik Bratland, Thea Sjøgren, Thea Sjøgren, Thea Sjøgren, Marte Heimli, Marte Heimli, Marte Heimli, Torgeir Tyssedal, Torgeir Tyssedal, Øyvind Bruserud, Øyvind Bruserud, Øyvind Bruserud, Stefan Johansson, Stefan Johansson, Stefan Johansson, Eystein Sverre Husebye, Eystein Sverre Husebye, Eystein Sverre Husebye, Bergithe Eikeland Oftedal, Bergithe Eikeland Oftedal, Bergithe Eikeland Oftedal, Anette Susanne Bøe Wolff, Anette Susanne Bøe Wolff, Anette Susanne Bøe Wolff   +28 more
doaj   +1 more source

BCAR1 (breast cancer anti-estrogen resistance 1) [PDF]

, 2012
Review on BCAR1 (breast cancer anti-estrogen resistance 1), with data on DNA, on the protein encoded, and where the gene is ...
Berrier, A
core   +1 more source

The Y chromosome sequence of the channel catfish suggests novel sex determination mechanisms in teleost fish

BMC Biology, 2019
Background Sex determination mechanisms in teleost fish broadly differ from mammals and birds, with sex chromosomes that are far less differentiated and recombination often occurring along the length of the X and Y chromosomes, posing major challenges ...
Lisui Bao, Changxu Tian, Shikai Liu, Yu Zhang, Ahmed Elaswad, Zihao Yuan, Karim Khalil, Fanyue Sun, Yujia Yang, Tao Zhou, Ning Li, Suxu Tan, Qifan Zeng, Yang Liu, Yueru Li, Yun Li, Dongya Gao, Rex Dunham, Kenneth Davis, Geoffrey Waldbieser, Zhanjiang Liu   +20 more
doaj   +1 more source

Novel Germline Mutation in BCAR1 in Two Siblings With Lung Cancer: a Possible Susceptibility Gene

, 2020
Background: Lung cancer is the most prevalent malignancy worldwide. Most patients were sporadic and carried somatic mutations in hotspot genes. At present, accumulating researches had identified several germline mutations that predispose patients to ...
K. Zhu, Yang-Chao Zhao, Lu Wu, Si-Jia Zhang, Y. Zong, Zhenyu Li, Qianwen Li, Fang Cheng, M. Rui   +8 more
semanticscholar   +1 more source

Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion [PDF]

, 2021
Background: Mutant TP53 interacts with other proteins to produce gain-of-function properties that contribute to cancer metastasis. However, the underlying mechanisms are still not fully understood.
Seshachalam, Veerabrahma Pratap, Itahana, Yoko, Ghosh, Sujoy, Itahana, Koji, Guo, Alvin Kunyao, Chow, Hui Ying   +5 more
core  

Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment [PDF]

, 2000
BACKGROUND: The product of the Bcar1/p130Cas (breast cancer resistance/p130Crk-associated substrate) gene causes resistance to antiestrogen drugs in human breast cancer cells in vitro.
Look, M.P. (Maxime), Klijn, J.G.M. (Jan), Dorssers, L.C.J. (Lambert), Kok, E.M. (Elisabeth), Foekens, J.A. (John), Brinkman, A. (Arend), Flier, S. (Silvia) van der, Meijer van Gelder, M.E. (Marion)   +7 more
core   +1 more source

Connecting SNPs in Diabetes: a spatial analysis of meta-GWAS Loci

Frontiers in Endocrinology, 2015
Meta-analyses of genome-wide association studies (GWAS) have improved our understanding of the genetic foundations of a number of diseases, including diabetes. However, SNPs that are identified by GWAS, especially those that fall outside of gene regions,
William Stewart Schierding, Justin Martin O'Sullivan, Justin Martin O'Sullivan   +2 more
doaj   +1 more source

BCAR1, phospho-BCAR1, p38 and phospho-p38 expression in NSCLC tissues and cells.

, 2013
A: Immunoblotting indicated either BCAR1 or phospho-p38(Thr180/Tyr182) levels in three NSCLC tissues (C) were significantly higher than in the adjacent normal tissues (N). But phospho-BCAR1 (Tyr410) and p38 levels in NSCLC and the adjacent normal tissues
Wei Huang (36889), Yao-Guang Jiang (324770), Bo Deng (324764), Jing-Hai Zhou (324772), Yong He (115255), Qun-You Tan (324767), Ru-Wen Wang (324765)   +6 more
core   +1 more source

High levels of BCAR1 predict poorer prognosis, and are correlated to activation of p38.

, 2013
A: The survival rate of BCAR1 high-expressed group was significantly lower than of low-expressed group (P = 0.001). B: Phospho-p38 positive cells was significantly and positively correlated with percentages of BCAR1 positive cells, in the 182 NSCLC ...
Wei Huang (36889), Yao-Guang Jiang (324770), Bo Deng (324764), Jing-Hai Zhou (324772), Yong He (115255), Qun-You Tan (324767), Ru-Wen Wang (324765)   +6 more
core   +1 more source

Multi-omics causal inference unravels arterial BCAR1 as a novel protective factor against intracranial aneurysm

International Journal of Surgery
Intracranial aneurysm (IA) is a prevalent cerebrovascular disorder, but its pathogenesis remains elusive. This study integrated transcriptome-wide association study (TWAS), two-sample Mendelian randomization (MR), Bayesian-based co ...
H. Ji, Haitao Liu, Hailan Yang, Yue Li, Yujing Han, Guicheng Kuang, Mamun Ahmed, A. Xiao, Yong-Bo Yang, Rong Wang, Liangxue Zhou, Haogeng Sun, Jian-Guo Xu, Shaoshan Hu, C. You, Yi Liu   +15 more
semanticscholar   +1 more source