Results 31 to 40 of about 2,056 (164)

Loss of p130Cas/Bcar1 impairs palatal mesenchymal expansion and causes cleft palate.

Scientific Reports
Palatogenesis is a complex developmental process that requires the coordinated growth, elevation, and fusion of palatal shelves. Disruption of these events results in cleft palate, which is one of the most common congenital, craniofacial anomalies ...
Tao Han, Jing Gao, Wei Wu, M. Nakatomi, I. Nakamura, H. Honda, S. Tsukamoto, Takenobu Katagiri, E. Jimi   +8 more
semanticscholar   +2 more sources

Increased BCAR1 Predicts Poor Outcomes of Non-small Cell Lung Cancer in Multiple-Center Patients

Annals of Surgical Oncology, 2013
Objective This study was designed to determine the prognostic value of BCAR1 expression and its associations with clinical-demographical characteristics in multiple centers of non-small cell lung cancer (NSCLC) patients.MethodsGene expression microarray (
Zhifu Sun, Bo Deng
exaly   +2 more sources

Association of the Breast Cancer Antiestrogen Resistance Protein 1 (BCAR1) and BCAR3 Scaffolding Proteins in Cell Signaling and Antiestrogen Resistance

Journal of Biological Chemistry, 2014
Background: BCAR1 (breast cancer antiestrogen resistance protein 1) and BCAR3 promote antiestrogen resistance and malignancy in breast cancer. Results: Mutations preventing the tight BCAR1-BCAR3 association disrupt downstream signaling events required ...
Elena Pasquale
exaly   +2 more sources

Exploring lncRNAs associated with human pancreatic islet cell death induced by transfer of adoptive lymphocytes in a humanized mouse model [PDF]

Frontiers in Endocrinology, 2023
BackgroundLong noncoding RNA (lncRNA)-mediated posttranscriptional and epigenetic landscapes of gene regulation are associated with numerous human diseases.
Md Munir Hossain, Md Munir Hossain, Regan Roat, Jenica Christopherson, Colette Free, Ansarullah, Brian James, Brian James, Zhiguang Guo   +8 more
doaj   +2 more sources

Cerebral furin deficiency causes hydrocephalus in mice [PDF]

Genes and Diseases
Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previously reported that cerebral overexpression of furin promotes cognitive functions in mice.
Shiqi Xie, Xiaoyong Xie, Jing Tang, Biao Luo, Jian Chen, Qixin Wen, Jianrong Zhou, Guojun Chen   +7 more
doaj   +2 more sources

Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery [PDF]

The Journal of Headache and Pain
Background Migraine, a debilitating neurological disorder with distinct subtypes (migraine with aura [MA] and migraine without aura [MO]), exhibits genetic and spatial heterogeneity that remains poorly understood.
Shuxu Wei, Yan Quan, Xinyi Li, Suiqin Zhong, Ling Xiao, Chao Yang, Ronghuai Shen, Xiaojia Lu, Lingbin He, Youti Zhang, Xianxi Huang   +10 more
doaj   +2 more sources

Germline mutation analyses of malignant ground glass opacity nodules in non-smoking lung adenocarcinoma patients [PDF]

PeerJ, 2021
Background Germline mutations play an important role in the pathogenesis of lung cancer. Nonetheless, research on malignant ground glass opacity (GGO) nodules is limited.
Wenjun Mao, Ruo Chen, Rongguo Lu, Shengfei Wang, Huizhu Song, Dan You, Feng Liu, Yijun He, Mingfeng Zheng   +8 more
doaj   +2 more sources

Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway

Oncogene, 2006
Christine Clarke, Geraldine O'Neill, A H Bouton   +2 more
exaly   +2 more sources

Promoting effect of breast cancer anti-estrogen resistance 1 on proliferation and growth of lung adenocarcinoma cells and potential networks of its interacting proteins

Di-san junyi daxue xuebao, 2020
Objective To explore the biological functions of breast cancer anti-estrogen resistance 1 (BCAR1, also known as p130cas) in the incidence and development of lung cancer, and investigate the potential networks of its interacting proteins.
MAO Chunguo, JIANG Shasha, FAN Xiaoqing, LONG Tan, JIN Hua, TAN Qunyou, DENG Bo   +6 more
doaj   +1 more source

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Cell Reports, 2021
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition.
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der   +36 more
doaj   +1 more source