Results 21 to 30 of about 2,056 (164)

Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion

British Journal of Cancer, 2020
Mutant TP53 interacts with other proteins to produce gain-of-function properties that contribute to cancer metastasis. However, the underlying mechanisms are still not fully understood.
Koji Itahana, Sujoy Ghosh, Alvin Guo
exaly   +2 more sources

BCAR1 facilitates the survival of lung adenocarcinoma cells by augmenting the unfolded protein response, autophagy, and the formation of vasculogenic mimicry

Biochimica Et Biophysica Acta - Molecular Basis of Disease
BACKGROUND Our objective was to elucidate the pivotal roles of BCAR1 in unfolded protein response (UPR), autophagy and vasculogenic mimicry (VM) formation, processes that essential for the metastasis of lung adenocarcinoma (LUAD) cells.
Hualiang Xiao, Fuqiang Dai, Bo Deng
exaly   +2 more sources

Identification of Resistance Genes in Breast Cancer Cells Treated with Fulvestrant and Ribociclib via Retroviral Screening and Integration Site Sequencing [PDF]

Cells
Around 30% of patients with hormone receptor-positive (HR+) breast cancer acquire resistance to endocrine therapy combined with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i), which are first-line treatments in metastatic settings.
Zhangzan Huang, Corine Beaufort, Jean Helmijr, Brian Zantboer, Giada Rozema, Camilla Muritti, Julia J. Whien, Anna Uijterwegen, Michele Massimino, John W. M. Martens, Maurice P. H. M. Jansen   +10 more
doaj   +2 more sources

The Role of Cysteine-Rich Protein 2 in Aortic Dissection: Implications for VSMC Phenotypic Modulation—CSRP2 Impedes the Progression of Aortic Dissection [PDF]

Biomolecules
Aortic dissection (AD) is a severe vascular condition marked by abrupt onset, rapid progression, and heightened mortality rates. Vascular smooth muscle cells (VSMCs), the predominant cellular component of the arterial media, are essential for maintaining
Can Liu, Xiangyu Wang, Cheng An, Shenglin Ge, Chengxin Zhang   +4 more
doaj   +2 more sources

Correction to: Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

Cell Communication and Signaling, 2018
Following publication of the original article [1], the authors reported an error in the name of the 11th author. The author’s name was incorrectly published as “Vincenzo Calautti”, instead of “Enzo Calautti”.
Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti, Sara Cabodi   +11 more
doaj   +2 more sources

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection. [PDF]

J Hepatobiliary Pancreat Sci
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Zou B, Jiang H, Ruan J, Yang D, Chen X, Cai S, Yi X.   +6 more
europepmc   +2 more sources

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma. [PDF]

Mol Carcinog
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Ham E, Boedeker K, Keating CR, Ye R, Montalbano F, Mankaruse S, Ding X, Rennhack JP, Qiu W.   +8 more
europepmc   +2 more sources

Integrative functional genomics analysis identifies pleiotropic genes for vascular diseases [PDF]

Nature Communications
Several vascular diseases including coronary artery disease, hypertension, stroke, and abdominal aortic aneurysm, have significant genetic underpinnings. Genome-wide association studies have unveiled many genetic loci associated with one or more of these
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Dedrick S. S. Song, Heming Zhang, Dominic P. Lee, Elisavet Karamanavi, Wei Yang, Jiapeng Chu, Runji Chen, Kim E. Haworth, Chukwuemeka George Anene-Nzelu, Hui Li, Matthew J. Denniff, Peter Y. Li, Yanhong Zhang, Xiaoxin Huang, Gavin E. Morris, Peter A. Greer, Emma J. Stringer, Haojie Yu, Roger S. Y. Foo, Gillian Douglas, Nilesh J. Samani, Tom R. Webb, Shu Ye   +27 more
doaj   +2 more sources

Association between RBMS1 gene rs7593730 and BCAR1 gene rs7202877 and Type 2 diabetes mellitus in the Chinese Han population. [PDF]

Acta Biochimica Polonica, 2018
Two recent studies found that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 are related to type 2 diabetes. However, the association of these loci with type 2 diabetes mellitus (T2DM) has not been examined in Chinese.
E. Kazakova, Mei-Jun Chen, Esma Jamaspishvili, Zhang Lin, Jingling Yu, Lu-Lu Sun, H. Qiao   +6 more
semanticscholar   +2 more sources

Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer [PDF]

Scientific Reports
Pancreatic cysts, particularly intraductal papillary mucinous neoplasms (IPMNs), pose a potential risk for progressing to pancreatic cancer (PC). This study investigates the genetic architecture of benign pancreatic cysts and its potential connection to ...
A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li   +7 more
doaj   +2 more sources