The role of p130Cas/BCAR1 adaptor protein in the pathogenesis of cardiovascular diseases: A literature review [PDF]
American Heart Journal PlusBreast cancer anti-estrogen resistance-1 (p130Cas/BCAR1) is an adaptor protein of the cas(Cas) family. This protein regulates multiple complex pathways in different organs including bones, pancreas, and immune and cardiovascular systems.
Ghazal Ghasempour Dabaghi
exaly +6 more sources
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract [PDF]
Cardiovascular Research, 2022 Aims The adapter protein p130Cas, encoded by the Bcar1 gene, is a key regulator of cell movement, adhesion, and cell cycle control in diverse cell types.
Paul Frankel, Ian Evans, Yuen Bun Tam
exaly +5 more sources
BCAR1 Protein Plays Important Roles in Carcinogenesis and Predicts Poor Prognosis in Non-Small-Cell Lung Cancer [PDF]
PLoS ONE, 2012 OBJECTIVE: Our previous study suggested the potential clinical implications of BCAR1 in non-small-cell lung cancer (NSCLC) (Mol Diagn Ther. 2011. 15(1): 31-40).
Bo Deng, Ru-Wen Wang
exaly +4 more sources
High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer
BMC Cancer, 2018 Background Breast cancer anti-estrogen resistance 1 (BCAR1/p130cas) is a hub for diverse oncogenic signaling cascades and promotes tumor development and progression. Methods To understand the effect of BCAR1 in prostate cancer, we analyzed its expression
Andrea Hinsch +2 more
exaly +5 more sources
Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair [PDF]
iScience, 2023 Summary: Creatine kinase (CK) is an essential metabolic enzyme mediating creatine/phosphocreatine interconversion and shuttle to replenish ATP for energy needs. Ablation of CK causes a deficiency in energy supply that eventually results in reduced muscle
Bo Yang +6 more
doaj +3 more sources
Interaction Network Provides Clues on the Role of BCAR1 in Cellular Response to Changes in Gravity [PDF]
Computation, 2021 When culturing cells in space or under altered gravity conditions on Earth to investigate the impact of gravity, their adhesion and organoid formation capabilities change. In search of a target where the alteration of gravity force could have this impact,
Johann Bauer +4 more
doaj +3 more sources
FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling [PDF]
International Journal of Biological Sciences, 2023 Flotillin-1 (FLOT1) is a member of the flotillin family and serves as a hallmark of lipid rafts involved in the process of signaling transduction and vesicular trafficking.
Wang R +12 more
exaly +3 more sources
BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A
Thoracic Cancer, 2020 Background This study was designed to investigate the effects of a novel carcinogenetic molecule, p130cas (breast cancer antiestrogen resistance protein 1 or BCAR1) on proliferation and cell growth in lung adenocarcinoma. The study also aimed to identify
Hua Jin, Bo Deng, Bo Deng
exaly +3 more sources
p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer? [PDF]
Frontiers in Cell and Developmental Biology, 2021 p130Cas/BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity, whose modular structure with various binding motifs, allows the formation of multi-protein signaling complexes.
Giorgia Centonze +5 more
doaj +3 more sources
Technology in Cancer Research & Treatment, 2020 Objective: To clarify the clinical significance of breast cancer anti-estrogen resistance protein 1 (BCAR1) expression in circulating tumor cells (CTCs) in the peripheral blood and tumor tissues in patients with early stage lung adenocarcinoma (ES-LUAD).
Shasha Jiang MD +4 more
doaj +2 more sources