Immunohistochemical Study of the BCAR1/p130Cas Protein in Non-Malignant and Malignant Human Breast Tissue [PDF]
International Journal of Biological Markers, 2001 BCAR1/p130Cas is a docking protein involved in intracellular signaling pathways and in vitro resistance of estrogen-dependent breast cancer cells to antiestrogens.
J A Foekens, T H van der Kwast
exaly +3 more sources
p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis [PDF]
Gene, 2015 BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the last years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli,
Paola Defilippi +2 more
exaly +3 more sources
NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. [PDF]
PLoS ONE, 2011 The Cas scaffolding proteins (NEDD9/HEF1/CAS-L, BCAR1/p130Cas, EFSSIN, and HEPL/CASS4) regulate cell migration, division and survival, and are often deregulated in cancer. High BCAR1 expression is linked to poor prognosis in breast cancer patients, while
Nadezhda Tikhmyanova, Erica A Golemis
doaj +3 more sources
Regulation of p130Cas/BCAR1 Expression in Tamoxifen-Sensitive and Tamoxifen-Resistant Breast Cancer Cells by EGR1 and NAB2 [PDF]
Neoplasia: An International Journal for Oncology Research, 2012 Elevated levels of p130Cas/BCAR1 (Crk-associated substrate/breast cancer antiestrogen resistance 1) are found in aggressive breast tumors and are associated with tamoxifen resistance of mammary cancers.
Joerg Kumbrink, Kathrin H. Kirsch
doaj +3 more sources
Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation [PDF]
Cell Communication and Signaling, 2018 Background p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling.
Maria del Pilar Camacho Leal +11 more
doaj +3 more sources
BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma [PDF]
International Journal on Biological Sciences, 2021 Background: We investigated the roles of breast cancer anti-estrogen resistance 1 (BCAR1/p130Cas) in the formation and immunoevasion of invasive circulating tumor cells (CTCs) in lung adenocarcinoma (LUAD). Methods: Biomarkers of CTCs including BCAR1 and
Chun-Guo Mao +12 more
semanticscholar +2 more sources
Novel germline mutation in lung cancer pedigrees establishes BCAR1 as a human cancer susceptibility gene: a case report. [PDF]
Ann Transl Med, 2022 Background Lung cancer is the most prevalent malignancy worldwide. Most cases are sporadic and carry somatic mutations in hotspot genes. However, accumulating studies have identified several germline mutations that predispose patients to lung cancer at ...
Zhu K +8 more
europepmc +2 more sources
BCAR1, a Human Homologue of the Adapter Protein p130Cas, and Antiestrogen Resistance in Breast Cancer Cells [PDF]
Journal of the National Cancer Institute, 2000 BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of
Lambert C J Dorssers, L C Dorssers
exaly +4 more sources
Blood, 2022 Understanding the functional role of mutated genes in cancer is required to translate the findings of cancer genomics into therapeutic improvement. BTG1 is recurrently mutated in the MCD/C5 subtype of diffuse large B cell lymphoma (DLBCL), which is ...
Lorric Delage +22 more
semanticscholar +2 more sources
P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis [PDF]
Scientific Reports, 2020 P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis.
L. Wisniewski +4 more
semanticscholar +3 more sources