Results 41 to 50 of about 2,056 (164)

Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer

Frontiers in Oncology, 2021
BackgroundBreast cancer is a malignancy and lethal tumor in women. Metastasis of breast cancer is one of the causes of poor prognosis. Increasing evidences have suggested that the competing endogenous RNAs (ceRNAs) were associated with the metastasis of ...
Da Qian, Da Qian, Da Qian, Qinghui Zheng, Danping Wu, Buyun Ye, Yangyang Qian, Tao Zhou, Jie Qiu, Xuli Meng   +9 more
doaj   +1 more source

The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells [PDF]

Breast Cancer Research and Treatment, 2010
To unravel the mechanisms underlying failure of endocrine therapy of breast cancer, we have previously executed a functional genetic screen and identified the adaptor protein BCAR1 to be causative for tamoxifen resistance.
A. Brinkman, D. de Jong, Sietske Tuinman, Najat Azaouagh, T. van Agthoven, L. Dorssers   +5 more
semanticscholar   +2 more sources

A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

eLife, 2021
Integrin adhesion complexes regulate cytoskeletal dynamics during cell migration. Adhesion activates phosphorylation of integrin-associated signaling proteins, including Cas (p130Cas, BCAR1), by Src-family kinases.
Elizabeth M Steenkiste, Jason D Berndt, Carissa Pilling, Christopher Simpkins, Jonathan A Cooper   +4 more
doaj   +1 more source

BCAR1/p130Cas expression in untreated and acquired tamoxifen-resistant human breast carcinomas

International Journal of Cancer, 2000
Mitch Dowsett, S R Johnston, L C Dorssers   +2 more
exaly   +2 more sources

The prognostic value of BCAR1 in patients with primary breast cancer. [PDF]

, 2004
Contains fulltext : 57138.pdf (Publisher’s version ) (Open Access)PURPOSE: BCAR1, the human homologue of the rat p130Cas protein, was identified in a functional screen for human breast cancer cell proliferation resistant to antiestrogen
Look, M.P., Grebenchtchikov, N.J., Sweep, CGJ, van Tienoven, ThH, Brinkman, A (Arend), Dorssers, L.C.J., Broekhoven, S.P. van, Foekens, J.A., Jong, D. de, Geurts-Moespot, A, de Jong, D (Diederick), Portengen, H., Meijer - Gelder, M, Dorssers, Lambert, Sweep, C.G.J., Dorssers, L.C., Peters, H.A., Geurts-Moespot, A., Span, P.N., Brinkman, A.B., Portengen, H (Henk), Tienoven, T.H. van, Foekens, John, Peters, HAAM (Harry), Grebenchtchikov, N, Meijer-van Gelder, M.E., Klijn, J.G.M., Broekhoven, SPJ (Simone), Klijn, Jan, Look, Maxime, Span, PN   +30 more
core   +2 more sources

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes. [PDF]

PLoS ONE, 2015
We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genome-wide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2 ...
Ren Matsuba, Kensuke Sakai, Minako Imamura, Yasushi Tanaka, Minoru Iwata, Hiroshi Hirose, Kohei Kaku, Hiroshi Maegawa, Hirotaka Watada, Kazuyuki Tobe, Atsunori Kashiwagi, Ryuzo Kawamori, Shiro Maeda   +12 more
doaj   +1 more source

Dcas supports cell polarization and cell-cell adhesion complexes in development. [PDF]

PLoS ONE, 2010
Mammalian Cas proteins regulate cell migration, division and survival, and are often deregulated in cancer. However, the presence of four paralogous Cas family members in mammals (BCAR1/p130Cas, EFS/Sin1, NEDD9/HEF1/Cas-L, and CASS4/HEPL) has limited ...
Nadezhda Tikhmyanova, Alexei V Tulin, Fabrice Roegiers, Erica A Golemis   +3 more
doaj   +1 more source

Perturbation of specific transcripts in peripheral blood mononuclear cells in breast cancer: A case- control pilot study [PDF]

Journal of Health and Social Sciences, 2022
Introduction: Breast cancer (BC) is the most common type of diagnosed cancer worldwide and the leading cause of cancer death in women and it is the second most frequent cancer-causing mortality for women worldwide.
Nadia PANERA, Vincenzo CAMISA, Maria Rita BRAGHINI, Emanuele COSCIA, Gabriele ARNESANO, Rita BRUGALETTA, Teresa GIGLIOTTI, Antonella CIABATTONI, Gabriella NUCERA, Lukasz SZARPAK, Giuseppe D’ERMO, Anna ALISI, Salvatore ZAFFINA   +12 more
doaj   +1 more source

Protein Annotation of Breast-cancer-related Proteins with Machine-learning Tools

Makara Journal of Science, 2020
One of the primary contributors to the mortality of women is breast cancer. Several approaches are used to cure it, but recurrence occurs in 79% of the cases because the underlying mechanism of the protein molecules is not carefully ex-amined.
Arli Aditya Parikesit , David Agustriawan, Rizky Nurdiansyah   +2 more
doaj   +1 more source

Cas phosphorylation regulates focal adhesion assembly

eLife, 2023
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar, Amanda Stainer, Julien Dubrulle, Christopher Simpkins, Jonathan A Cooper   +4 more
doaj   +1 more source