Results 61 to 70 of about 2,056 (164)
Journal of Diabetes Investigation, EarlyView.Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen +6 more
wiley +1 more source
The interaction of p130Cas with PKN3 promotes malignant growth
Molecular Oncology, 2019 Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes ...
Jakub Gemperle +4 more
doaj +1 more source
The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
eLife, 2016 Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
doaj +1 more source
, 2013 A: At least an 80% reduction in mRNA of BCAR1 in A549-BCAR1-RNAi cells was confirmed by real-time RT-PCR. B: Colony forming units of A549-BCAR1-RNAi were detectably less than of A549-negative control cells, eleven days after plating.
Wei Huang (36889) +6 more
core +1 more source
Personal Neoantigens From Patients With NSCLC Induce Efficient Antitumor Responses
Frontiers in Oncology, 2021 ObjectiveTo develop a neoantigen-targeted personalized cancer treatment for non-small cell lung cancer (NSCLC), neoantigens were obtained from collected human lung cancer samples, and the utility of neoantigen and neoantigen-reactive T cells (NRTs) was ...
Wei Zhang +10 more
doaj +1 more source
Biopolymers, Volume 117, Issue 5, September 2026.The two phosphorylation sites within the Gab1 fragment 142‐203 exhibit distinct structural characteristics. Tyr162 is in a disordered region, Y183 in a helical segment. ABSTRACT The biological function of intrinsically disordered proteins is frequently coupled to short linear motifs, which serve as protein binding sites.
Anne Dietrich +5 more
wiley +1 more source
Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes
Advanced Science, Volume 13, Issue 31, 4 June 2026.This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang +8 more
wiley +1 more source
Role of cytoskeleton-related proteins in the acrosome reaction of Eriocheir sinensis spermatozoa
BMC Genomic Data, 2023 Cytoskeleton-related proteins are essential for cell shape maintenance and cytoskeleton remodeling. The spermatozoa of Eriocheir sinensis (Chinese mitten crab) have a unique cellular structure, and the mechanism of spermatozoal metamorphosis during the ...
Yulian Tang +6 more
doaj +1 more source
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
Genome Medicine, 2021 Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance ...
Evangelina López de Maturana +76 more
doaj +1 more source