Results 91 to 100 of about 57,075 (256)
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Cancer Science, EarlyView.UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong +7 more
wiley +1 more source
Cancer Science, EarlyView.Ketogenic diet and β‐hydroxybutyrate (β‐HB) suppress bladder cancer growth through direct anti‐tumor mechanisms and enhance anti‐PD‐L1 immunotherapy efficacy. β‐HB upregulates PD‐L1 via JAK2‐STAT3 activation and remodels the tumor immune microenvironment, sensitizing tumors to immune checkpoint blockade. ABSTRACT The limited clinical efficacy of immune
Yuan Zeng +6 more
wiley +1 more source
Evaluating Encodings for Bivariate Edges in Adjacency Matrices
Computer Graphics Forum, EarlyView.Abstract We present the first empirical evaluation of techniques for encoding distributions of quantitative edge values within adjacency matrices. In many real‐world networks, edges represent not a single value but a set of measurements. While adjacency matrices preserve structural clarity, their compact cells limit the simultaneous display of multiple
J. Acosta‐Hernández, A. Lex, T. He
wiley +1 more source
Cell Proliferation, EarlyView.Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song +15 more
wiley +1 more source
SUBDUE‐3: SUB‐urothelial DUrvalumab‐89zirconium injEction; a phase 0 biodistribution study protocol
BJU International, EarlyView.
Kevin G. Keane +9 more
wiley +1 more source
Ecography, EarlyView.Species distribution models are key to evaluate how climate change threatens European forests and tree species distributions. However, current models struggle to integrate ecophysiological processes. Mechanistic models are complex and have high parameter requirements.
Anne Baranger +6 more
wiley +1 more source
Gender, Work &Organization, EarlyView.ABSTRACT Over the last decade, policy actors have produced a surge of “future of work” reports that reimagine workers through the dual logics of digitalization and human capital. Drawing on 25 policy documents (WEF, World Bank, OECD, EU, and major consultancies) and combining Bacchi and Goodwin's WPR approach with decolonial feminist theory, this paper
Muneeb Ul Lateef Banday
wiley +1 more source