Results 91 to 100 of about 806,785 (277)

Association of BCG vaccination policy with prevalence and mortality of COVID-19

medRxiv, 2020
There is some evidence that tuberculosis vaccine bacillus Calmette-Guérin (BCG) has non-specific beneficial effects against non-related infections. Here, we examined the possible association between BCG vaccination with prevalence and mortality by COVID ...
G. Sala, Rik Chakraborti, A. Ota, Tsuyoshi Miyakawa   +3 more
semanticscholar   +1 more source

Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial

EClinicalMedicine, 2022
Summary Background BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus ...
C. Upton, R. V. van Wijk, Laurynas Mockeliunas, Ulrika S. H. Simonsson, Kirsten McHarry, G. V. D. van den Hoogen, Chantal Muller, A. von Delft, H. van der Westhuizen, R. van Crevel, G. Walzl, P. Baptista, J. Peter, A. Diacon   +13 more
semanticscholar   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

The influence of previous exposure to environmental mycobacteria on the interferon-gamma response to bacille Calmette-Guérin vaccination in southern England and northern Malawi.

, 2006
We report a large study of the effect of BCG vaccination on the in vitro 6-day whole blood interferon-gamma (IFN-gamma) response to antigens from eight species of mycobacteria among schoolchildren in south-eastern England, where bacille Calmette-Guérin ...
Crampin, A.C., Nazareth, B., Stenson, S, Branson, K, Floyd, S., Weir, RE, Branson, K., Fine, P.E.M., Sichali, L., Chaguluka, SD, Chaguluka, S.D., Donovan, L., Weir, R.E., Stanley, C., Donovan, L, Black, G.F., Nazareth, B, Stenson, S., Dockrell, H.M., Sichali, L, Crampin, AC, Dockrell, HM, Black, GF, Stanley, C, Fine, PEM, Floyd, S   +25 more
core   +1 more source

Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy. [PDF]

, 2009
Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents.
Gorak-Stolinska, P., Crampin, A.C., Fine, Paul E.M., Paul E M Fine (16181840), Newport, Melanie J, Mvula, Hazzie, Ben-Smith, A., Weir, Rosemary E., Hazzie Mvula (271278), Fine, P.E., Nuala McGrath (230042), Crampin, Amelia C, Keith Branson (239422), Mvula, H., Hazel M Dockrell (10414616), Patricia Gorak-Stolinska (356875), McGrath, Nuala, Blitz, R., Gorak-Stolinska, Patricia, Branson, K., Ben‐Smith, Anne, Fine, Paul EM, Amelia C Crampin (10281422), Crampin, Amelia C., Ben-Smith, Anne, Weir, R.E., McGrath, N., Dockrell, Hazel M., Floyd, Sian, Rose Blitz (356877), Newport, M.J., Gorak‐Stolinska, Patricia, Anne Ben-Smith (244056), Blitz, Rose, Melanie Newport (4461202), Lalor, Maeve K., Lalor, M.K., Maeve K Lalor (16181825), Dockrell, H.M., Rosemary E Weir (16181828), Sian Floyd (239400), Weir, Rosemary E, Lalor, Maeve K, Dockrell, Hazel M, Newport, Melanie J., Branson, Keith   +45 more
core   +1 more source

Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette–Guérin Russia Vaccination

Frontiers in Immunology, 2017
Bacillus Calmette–Guérin (BCG), the only licensed vaccine against tuberculosis, has been shown to provide heterologous protection against unrelated pathogens and enhance antibody responses to several routine expanded program on immunization (EPI ...
Fatoumatta Darboe, Jane U. Adetifa, John Reynolds, Safayet Hossin, Magdalena Plebanski, Magdalena Plebanski, Mihai G. Netea, Sarah L. Rowland-Jones, Sarah L. Rowland-Jones, Jayne S. Sutherland, Katie L. Flanagan, Katie L. Flanagan, Katie L. Flanagan   +12 more
doaj   +1 more source

Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis

medRxiv, 2020
COVID-19 started in Hubei province in China and has spread to 210 countries within 3 months. The statistic of COVID-19 across the world is reported daily, providing a dynamic perspective for each country.
D. Klinger, I. Blass, Nadav Rappoport, M. Linial   +3 more
semanticscholar   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom. [PDF]

, 2004
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial ...
Elizabeth King, King, Elizabeth, Jarman, Elizabeth, Hazel M. Dockrell, Lifted Sichali, Fine, Paul E.M., Blackwell, Jenefer M., Weir, Rosemary E., Elizabeth Jarman, Sally Stenson, Nazareth, Bernadette, Warndorff, David K., Crampin, Amelia C, Black, Gillian F, Stenson, Sally, Mwaungulu, Lorren, Amelia C. Crampin, Linda Donovan, Blackwell, Jenefer M, Rosemary E. Weir, Paul E. M. Fine, Sian Floyd, Bernadette Nazareth, Fine, Paul EM, David K. Warndorff, Black, Gillian F., Crampin, Amelia C., Dockrell, Hazel M., Jenefer M. Blackwell, Floyd, Sian, Chaguluka, Steven D, Lorren Mwaungulu, Sichali, Lifted, Donovan, Linda, Steven D. Chaguluka, Warndorff, David K, Weir, Rosemary E, Chaguluka, Steven D., Dockrell, Hazel M, Ngwira, Bagrey, Bagrey Ngwira, Gillian F. Black   +41 more
core   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source