Results 71 to 80 of about 27,025 (201)

Knowledge and Perception of Caregivers Regarding Adverse Events Following Immunization and Associated Predictors at Hospitals in Osogbo, Southwestern Nigeria: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Adverse events following immunization (AEFI) can erode trust in vaccines and contribute to immunization dropout. Caregivers usually observe an AEFI first and decide whether it is reported and whether the child returns for later doses, yet their knowledge and perception are rarely assessed together.
Funso Abidemi Olagunju, Samuel Olorunyomi Oninla, Sunday Charles Adeyemo, Abimbola Ololade Odeyemi, Kehinde Awodele, Efeturi Agelebe, Abisola Oluwatoyin Omoboyeje, Muritala Adewale Ibrahim, Ayodeji Oluwaseun Ogungbemi, Ayodele Raphael Ajayi, Eniola Dorcas Olabode, Oladunni Opeyemi, Olusola Adetunji Oyedeji   +12 more
wiley   +1 more source

Burden and Correlates of Multiple Chronic Infections and Their Associations With Cancer Incidence in Chinese Adults: A Large Case‐Cohort Study

International Journal of Cancer, Volume 159, Issue 5, Page 1282-1295, 1 September 2026.
While several oncogenic pathogens cause site‐specific cancers, uncertainties remain about many other chronic infections and combined pathogen effects, especially in non‐Western populations. Using a large case–cohort study nested within the China Kadoorie Biobank, the authors found that co‐infection was common, with a mean of 10 pathogens per individual.
Ling Yang, Jonathan Clarke, Lea Kröller, Christiana Kartsonaki, Hannah Fry, Rima Jeske, Andrew Gordon, Sarah Clark, Michael Hill, Daniel Avery, Yiping Chen, Huaidong Du, Jun Lv, Dianjianyi Sun, Canqing Yu, Liming Li, Iona Y. Millwood, Tim Waterboer, Zhengming Chen, on behalf of the China Kadoorie Biobank Collaborative Group, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Liming Li, Jun Lv, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Yuting Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Lang Pan, Xiao Han, Honglu Bian, Xinxin Chen, Daniel Avery, Maxim Barnard, Derrick Bennett, Ruth Boxall, Yiping Chen, Zhengming Chen, Jonathan Clarke, Robert Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Prapthi Harish, Pek Kei Im, Andri Iona, Christiana Kartsonaki, Kshitij Kolhe, Hubert Lam, Kuang Lin, James Liu, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Maruf Sarder, Dan Schmidt, Becky Stevens, Iain Turnbull, Robin Walters, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Zengchang Pang, Ruqin Gao, Kunzheng Lv, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Liang Cheng, Xiaocao Tian, Hua Zhang, Dan Hu, Xiaoyan Zheng, Yujie Wang, Wei Sun, Shichun Yan, Chi Wang, Zhenyuan Wu, Lishun Zhai, Zhaoxi Pang, Shiwen Dong, Li Liu, Dapeng Yin, Bin He, Ying Liu, Xingren Wang, Tingting Ou, Xiangyang Zheng, Dewei Zheng, Shuai Yang, Lihui Li, Xingjiao Chen, Yan Xu, Jinyi Zhou, Ran Tao, Jian Su, Xikang Fan, Xuejia Chen, Yuxiao Huang, Yan Lu, Yujie Hua, Li Xing, Shuxian Wang, Jianrong Jin, Juping Ma, Jinchao Liu, Kaifei Zhu, Hongfu Ren, Xingfeng Shen, Ge Zhong, Wei Mao, Zhenzhen Lu, Yanxu Zhong, Lifang Zhou, Rong Pan, Jian Lan, Xiaoping Tan, Jinxue Tan, Yishan Xie, Liuping Wei, Liyuan Zhou, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Zhuo Wang, Yujin He, Mingqiang Yuan, Ling Wang, Xiaofang Chen, Zhaodong Wang, Qiang Sun, Yang Lin, Faqing Chen, Xiaolan Ren, Lijun Chang, Feiming Zhong, Jianjun Feng, Weijie Hu, Xiaofang Zhang, Yalin Chen, Honghong Wang, Jun Wang, Linqi Diao, Zhiwei Han, Dengjun Zhu, Kai Kang, Shixian Feng, Wenjie Yang, Huizi Tian, Yali Yan, Bing Han, Li Gao, Shaofang Li, Tianfang Xing, Wei Tang, Xiaolin Li, Huarong Sun, Xiaocong Zhao, Ying Li, Chen Hu, Pan He, Xukui Zhang, Yuanyuan Jin, Lan Luo, Min Yu, Ruying Hu, Hao Wang, Weiwei Gong, Jieming Zhong, Meng Wang, Chunxiao Xu, Keqing Gong, Hao Xu, Yuan Cao, Kaixu Xie, Lingli Chen, Xiaomei Tu, Junlong Pan, Xiaojun Li, Li Yin, Huilin Liu, Yuan Liu, Lei Yin, Xian Xie, Jing Wang, Bo Xiao, Zongwei Deng, Yuan Peng, Libo Zhang, Chan Qu, li Deng, Qili Jiang, Yanling Chen   +212 more
wiley   +1 more source

The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum

BMC Immunology
Background Bacillus Calmette–Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against malaria.
NL Messina, M Wang, EK Forbes, B Freyne, WP Hasang, S Germano, R Bonnici, F Summons, K Gardiner, S Donath, R Gordon, SJ Rogerson, N Curtis   +12 more
doaj   +1 more source

MMP9 Knockout by CRISPR‐Cas9 Reduces Bladder Cancer Malignancy But Does Not Synergize With BCG and Anti‐PD‐L1 in an Orthotopic Mouse Model

IUBMB Life, Volume 78, Issue 9, September 2026.
ABSTRACT Bladder cancer (BC) is the 10th most common cancer worldwide, accounting for approximately 5% of new cases. Several factors contribute to tumor progression, including increased MMP9. Recently, CRISPR‐Cas9 and immunotherapy have offered high specificity for treatments; therefore, we edited MMP9 using CRISPR‐Cas9 methodology to inhibit ...
Juliana Alves de Camargo, Maria Carolina Lee, Milena Monteiro de Souza, Luana Pereira da Silva, Giovanna Caetano Vilas Boas, Karina Serafim da Silva, Carolina Mie Mioshi, Ruan Cesar Aparecido Pimenta, Patrícia Candido, Iran Amorim da Silva, Ericka Barbosa Trarbach, Katia Ramos Moreira Leite, William Carlos Nahas, Sabrina Thalita dos Reis   +13 more
wiley   +1 more source

BCG vaccination: a role for vitamin D?

PLoS ONE, 2011
BackgroundBCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis.
Maeve K Lalor, Sian Floyd, Patricia Gorak-Stolinska, Rosemary E Weir, Rose Blitz, Keith Branson, Paul E Fine, Hazel M Dockrell   +7 more
doaj   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Pediatric Tuberculosis in North Kivu: The Urgency of a Targeted Response to a Forgotten Childhood Disease

Public Health Challenges, Volume 5, Issue 3, September 2026.
ABSTRACT Pediatric tuberculosis remains a neglected health emergency, particularly in fragile contexts such as North Kivu province in the Democratic Republic of Congo. While more than one million children contract tuberculosis each year worldwide, the majority of cases remain underdiagnosed, resulting in preventable morbidity and mortality.
Germain Cebweru Murhola, Christian Tague, Dujardin Makeda, Joshua Ekouo, Hermann Yokolo, Aymar Akilimali, Criss Koba Mjumbe   +6 more
wiley   +1 more source

Comprehensive Immunisation Among Children Aged 12–23 Months in India—A Multilevel Modelling Analysis From the National Family Health Survey (2015–21)

Public Health Challenges, Volume 5, Issue 3, September 2026.
ABSTRACT Under‐5 child mortality due to vaccine preventable diseases (VPDs) contributes to an estimated burden of ∼5.2 million deaths globally, mostly within low‐ and middle‐income countries (LMICs). Despite ongoing efforts to expand immunisation coverage, gaps in immunisation remain a persistent public health concern, underscoring the need to examine ...
Mansi Malik, Saurav Basu, Siaa Girotra, Satyajit Kundu   +3 more
wiley   +1 more source

Latent Tuberculosis and Associated Factors Among Adults Living With HIV in Kinshasa, Democratic Republic of the Congo: A Cross‐Sectional Study

Public Health Challenges, Volume 5, Issue 3, September 2026.
Latent tuberculosis infection is common among adults living with HIV in Kinshasa. Advanced immunosuppression, previous TB exposure, and contact with active TB cases were independently associated with LTBI, supporting systematic screening and targeted tuberculosis preventive therapy.
José Mutambayi Kadima, Aliocha Natuhoyila Nkodila, Pascal Tshindele Lutumba, Jean‐René Kabangu M'buyamba, Placide Kingebeni Mbala, Jeremie Masidi Muwonga, Marie‐Joelle Sifa Muchanga, Daniel Mukadi‐Bamuleka, Marie‐José Bajani Kabedi, Mecky Isaac Matee, Jean Marie Ntumba Kayembe   +10 more
wiley   +1 more source

UBE2C‐Mediated CD147‐CTLA‐4 Axis Promotes T Cell Exhaustion and Immunosuppressive Microenvironment in Bladder Cancer

Cancer Science, Volume 117, Issue 9, Page 2366-2378, September 2026.
UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong, Ting Hong, Xinyu Liu, Peixiu Yao, Weiqiang Lin, Guoyuan Liu, Huihong Guan, Yonghai Zhang   +7 more
wiley   +1 more source