Results 71 to 80 of about 806,785 (277)

Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining. [PDF]

, 2010
BACKGROUND: The vaccine efficacy reported following Mycobacterium bovis Bacillus Calmette Guerin (BCG) administration to UK adolescents is 77% and defining the cellular immune response in this group can inform us as to the nature of effective immunity ...
Natalie ER Beveridge, Rose Blitz, Steven G Smith, Dockrell Hazel M, Worth Andrew, Hazel M Dockrell, Smith, Steven G, McShane Helen, Maeve K Lalor, Gorak-Stolinska, Patricia, Helen McShane, Andrew Worth, Blitz, Rose, Beveridge Natalie ER, Smith Steven G, Lalor Maeve K, Worth, Andrew, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Beveridge, Natalie ER, Patricia Gorak-Stolinska, McShane, Helen, Blitz Rose   +23 more
core   +1 more source

A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.

PLoS ONE, 2010
BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis.
Yenny Djuardi, Erliyani Sartono, Heri Wibowo, Taniawati Supali, Maria Yazdanbakhsh   +4 more
doaj   +1 more source

BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner.

Journal of Clinical Investigation, 2020
BACKGROUND Induction of innate immune memory, also termed trained immunity, by the anti-tuberculosis vaccine Bacillus Calmette-Guérin (BCG) contributes to protection against heterologous infections.
V. Koeken, L. D. de Bree, V. Mourits, S. Moorlag, J. Walk, B. Cirovic, R. Arts, M. Jaeger, Helga Dijkstra, Heidi Lemmers, L. Joosten, C. Benn, R. van Crevel, M. Netea   +13 more
semanticscholar   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial

Trials, 2017
Background Bacillus Calmette-Guérin (BCG) vaccination may have nonspecific effects, i.e., effects on childhood morbidity and mortality that go beyond its effect on the risk of childhood tuberculosis (TB).
Victoria Nankabirwa, James K. Tumwine, Olive Namugga, Thorkild Tylleskär, Grace Ndeezi, Bjarne Robberstad, Mihai G. Netea, Halvor Sommerfelt   +7 more
doaj   +1 more source

Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series

Biomedicines, 2023
Vaccination with Bacillus Calmette–Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID).
Daniele Canarutto, Chiara Oltolini, Federica Barzaghi, Valeria Calbi, Maddalena Migliavacca, Francesca Tucci, Vera Gallo, Giulia Consiglieri, Francesca Ferrua, Salvatore Recupero, Maria Celia Cervi, Hamoud Al-Mousa, Anna Pituch-Noworolska, Chiara Tassan Din, Paolo Scarpellini, Paolo Silvani, Claudia Fossati, Miriam Casiraghi, Daniela Maria Cirillo, Antonella Castagna, Maria Ester Bernardo, Alessandro Aiuti, Maria Pia Cicalese   +22 more
doaj   +1 more source

Circadian rhythm influences induction of trained immunity by BCG vaccination.

Journal of Clinical Investigation, 2020
BACKGROUND The anti-tuberculosis vaccine Bacillus Calmette-Guérin (BCG) reduces overall infant mortality. Induction of innate immune memory, also termed trained immunity, contributes towards protection against heterologous infections.
L. D. de Bree, V. Mourits, V. Koeken, S. Moorlag, Robine Janssen, Lukas Folkman, D. Barreca, Thomas Krausgruber, Victoria Fife-Gernedl, B. Novaković, R. Arts, Helga Dijkstra, Heidi Lemmers, C. Bock, L. Joosten, R. van Crevel, C. Benn, M. Netea   +17 more
semanticscholar   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda. [PDF]

, 2012
BACKGROUND: Globally, BCG vaccination varies in efficacy and has some non-specific protective effects. Previous studies comparing BCG strains have been small-scale, with few or no immunological outcomes and have compared TB-specific responses only.
Webb, Emily L, Nampijja, Margaret, Anderson, Elizabeth J, Mawa, Patrice A, Lyadda, Nancy, Elliott, Alison M, Kizza, Moses   +6 more
core   +1 more source

Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

Heliyon
Background: The current prophylactic tuberculosis vaccine Bacille Calmette-Guérin (BCG), was derived in the 1920s, but the humoral immune responses induced by BCG vaccination have not been fully elucidated to date.
Yan-Qing Chen, Shu-Hui Cao, Xin-Yu Yang, Yi Liu, Chuan-You Li   +4 more
doaj   +1 more source