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Epidemiology of childhood tuberculosis after ceasing universal Bacillus Calmette–Guérin vaccination

Scientific Reports, 2021
Universal Bacillus Calmette–Guérin (BCG) vaccination is recommended in countries with high tuberculosis (TB) burden. Nevertheless, several countries have ceased universal BCG vaccination over the past 40 years, with scarce comparative epidemiological ...
Sayori Kobayashi +4 more
doaj +1 more source

Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial

Trials, 2017
Background Bacillus Calmette-Guérin (BCG) vaccination may have nonspecific effects, i.e., effects on childhood morbidity and mortality that go beyond its effect on the risk of childhood tuberculosis (TB).
Victoria Nankabirwa +7 more
doaj +1 more source

Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination

Clinical & Translational Immunology
Objectives Bacille Calmette–Guérin (BCG) vaccination has off‐target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune responses to ...
Nicole L Messina +23 more
doaj +1 more source

Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

Heliyon
Background: The current prophylactic tuberculosis vaccine Bacille Calmette-Guérin (BCG), was derived in the 1920s, but the humoral immune responses induced by BCG vaccination have not been fully elucidated to date.
Yan-Qing Chen +4 more
doaj +1 more source

Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease

Journal of International Medical Research, 2018
Objective The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD).
Tooru Araki +7 more
doaj +1 more source

Is BCG vaccination causally related to reduced COVID‐19 mortality?

EMBO Molecular Medicine, 2020
The ongoing severe acute respiratory sickness coronavirus 2 (SARS‐CoV‐2) pandemic has resulted in more than 3,600,000 detected cases of COVID‐19 illness and nearly 260,000 deaths worldwide as of May 6, 2020.
Masayuki Miyasaka
doaj +1 more source

Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette–Guérin Russia Vaccination

Frontiers in Immunology, 2017
Bacillus Calmette–Guérin (BCG), the only licensed vaccine against tuberculosis, has been shown to provide heterologous protection against unrelated pathogens and enhance antibody responses to several routine expanded program on immunization (EPI ...
Fatoumatta Darboe +12 more
doaj +1 more source

BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)

BMJ Open, 2021
Introduction BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established safety profile, BCG is a ...
Donna Legge +534 more
doaj +1 more source

Accelerated Bacille Calmette-Guérin reactions: More than meets the eye

Heliyon
An accelerated local injection site reaction following Bacille Calmette-Guérin (BCG) vaccination has been associated with underlying active tuberculosis (TB) in high TB-prevalence settings.
Paola Villanueva +16 more
doaj +1 more source

Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge. [PDF]

PLoS ONE, 2012
Mycobacterium bovis is the causative agent of tuberculosis in cattle but also infects other animals, including humans. Previous studies in cattle have demonstrated that the protection induced by BCG is not complete.
Caroline Rizzi +13 more
doaj +1 more source

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