Results 21 to 30 of about 806,785 (277)

Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination

Heliyon, 2023
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘
Paola Villanueva, Nigel W. Crawford, Mariana Garcia Croda, Simone Collopy, Bruno Araújo Jardim, Tyane de Almeida Pinto Jardim, Laurens Manning, Michaela Lucas, Helen Marshall, Cristina Prat-Aymerich, Alice Sawka, Ketaki Sharma, Darren Troeman, Ushma Wadia, Adilia Warris, Nicholas Wood, Nicole L. Messina, Nigel Curtis, Laure F. Pittet   +18 more
doaj   +1 more source

BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals

International Journal of Infectious Diseases, 2021
Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jeyadeepa, Nandhini Selvaraj, Dinesh Ashokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +1 more source

BCG vaccination impact on mortality and recovery rates in COVID-19: A meta-analysis

Monaldi Archives for Chest Disease, 2021
COVID-19 is a pandemic caused by SARS-CoV-2 virus which is a very worrisome public health emergency. In this study, we compared the mortality rate and recovery rate in countries with and without BCG vaccination policy.
Surjit Singh, Daisy Khera, Ankita Chugh, Sameer Khasbage, Pushpinder S. Khera, Vinay Kumar Chugh   +5 more
doaj   +1 more source

BCG vaccination stimulates Integrated Organ Immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Nature Immunology, 2023
Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. However, the underlying mechanisms remain mysterious.
Audrey Lee, K. Floyd, Shengyang Wu, Zhuo-Qing Fang, Tze-Kai Tan, H. M. Froggatt, John M. Powers, S. Leist, K. Gully, Miranda L. Hubbard, Chunfeng Li, Harold Hui, D. Scoville, Alistaire Ruggiero, Yan Liang, A. Pavenko, Victor Lujan, R. Baric, Garry P. Nolan, Prabhu S. Arunachalam, M. Suthar, B. Pulendran   +21 more
semanticscholar   +1 more source

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis

Lancet Global Health, 2022
Summary Background BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We
L. Martinez, Olivia Cords, Qiao Liu, C. Acuña-Villaorduña, Maryline Bonnet, G. J. Fox, A. C. Carvalho, P. Chan, J. Croda, P. Hill, E. López-Varela, Simon Donkor, K. Fielding, S. Graham, M. Espinal, B. Kampmann, A. Reingold, H. Huerga, J. Villalba, L. Grandjean, G. Sotgiu, U. Egere, Sarman Singh, Li-Mei Zhu, C. Lienhardt, J. Denholm, J. Seddon, C. Whalen, A. García-Basteiro, R. Triasih, Cheng Chen, Jitendra Singh, Li-Min Huang, S. Sharma, D. Hannoun, H. Del Corral, A. Mandalakas, L. Malone, D. Ling, A. Kritski, Catherine M. Stein, R. Vashishtha, F. Boulahbal, Chi-Tai Fang, W. Boom, E. Netto, A. C. Lemos, A. Hesseling, A. Kay, E. Jones-López, C. Horsburgh, C. Lange, J. Andrews   +52 more
semanticscholar   +1 more source

Mapping BCG vaccination coverage in Ethiopia between 2000 and 2019

BMC Infectious Diseases, 2022
Introduction The Bacille-Calmette–Guerin (BCG) vaccination remains the primary strategy to prevent severe disseminated TB in young children, particularly in high TB-burden countries such as Ethiopia.
Kendalem Asmare Atalell, Mulat Asrade Alemayehu, Nahom Worku Teshager, Getaneh Mulualem Belay, Tewodros Getaneh Alemu, Degefaye Zelalem Anlay, Amare Wondim, Kefyalew Addis Alene   +7 more
doaj   +1 more source

BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

mBio, 2023
While several BCG trials in adults were conducted during the 2019 coronavirus disease epidemic, our data set is the most comprehensive to date, because we included serologically confirmed infections in addition to self-reported positive SARS-CoV-2 test ...
Juana Claus, T. ten Doesschate, Cindy I. Gumbs, C. van Werkhoven, T. W. van der Vaart, A. Janssen, G. Smits, R. V. van Binnendijk, F. V. D. van der Klis, D. van Baarle, F. Paganelli, H. Leavis, L. M. Verhagen, S. Joosten, M. Bonten, M. Netea, J. H. van de Wijgert   +16 more
semanticscholar   +1 more source

BCG vaccination induces innate immune memory in gamma delta T cells in humans.

Journal of Leukocyte Biology, 2023
Bacillus Calmette-Guérin (BCG) vaccine is well-known for inducing trained immunity in myeloid and natural killer cells, which can explain its cross-protective effect against heterologous infections.
Tsz K. Suen, S. Moorlag, Wen-Chao Li, Charlotte J. de Bree, V. Koeken, V. Mourits, Helga Dijkstra, Heidi Lemmers, Jaydeep Bhat, Cheng-Jian Xu, L. Joosten, J. Schultze, Yang Li, K. Placek, M. Netea   +14 more
semanticscholar   +1 more source

The influence of prior exposure to environmental mycobacteria on the IFN-(gamma) response to BCG vaccination in southern England and northern Malaw [PDF]

, 2006
We report a large study of the effect of BCG vaccination on the in vitro 6-day whole blood interferon-gamma (IFN-γ) response to antigens from eight species of mycobacteria among schoolchildren in south-eastern England, where bacille Calmette–Guérin (
Donovan, L, Black, G, Nazareth, B, Sichali, L, Chaguluka, S, Weir, R, Stenson, S, Branson, K, Crampin, A, Dockrell, HM, Stanley, C, Floyd, S, Fine, P   +12 more
core   +4 more sources

Decreased Expression of CD314 by NK Cells Correlates with Their Ability to Respond by Producing IFN-γ after BCG Moscow Vaccination and Is Associated with Distinct Early Immune Responses

Vaccines, 2023
The immune response to vaccines is complex and results in various outcomes. BCG vaccination induces innate and specific responses that can lead to protection against tuberculosis, and cross-protection against other infections.
Adeliane Castro da Costa, Lília Cristina de Souza Barbosa, André Kipnis, Ana Paula Junqueira-Kipnis   +3 more
doaj   +1 more source