Results 1 to 10 of about 27,025 (201)

Long-term effects of BCG vaccination on telomere length and telomerase activity [PDF]

iScience
Summary: This study explores the effects of Bacillus Calmette-Guérin (BCG) vaccination on telomere maintenance, an aging-related process, in immune cells.
Ozlem Bulut, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Charlotte J. de Bree, Vera P. Mourits, Gizem Kilic, Priya A. Debisarun, Marijke P.A. Baltissen, Joost H.A. Martens, Jorge Domínguez-Andrés, Leo A.B. Joosten, Mihai G. Netea   +11 more
doaj   +2 more sources

Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity [PDF]

Heliyon
Background: The current prophylactic tuberculosis vaccine Bacille Calmette-Guérin (BCG), was derived in the 1920s, but the humoral immune responses induced by BCG vaccination have not been fully elucidated to date.
Yan-Qing Chen, Shu-Hui Cao, Xin-Yu Yang, Yi Liu, Chuan-You Li   +4 more
doaj   +2 more sources

BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination [PDF]

Nature Communications
Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial
Krista E. van Meijgaarden, Wenchao Li, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Hans J. P. M. Koenen, Leo A. B. Joosten, Annapurna Vyakarnam, Asma Ahmed, Srabanti Rakshit, Vasista Adiga, Tom H. M. Ottenhoff, Yang Li, Mihai G. Netea, Simone A. Joosten   +13 more
doaj   +2 more sources

Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination

Heliyon, 2023
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘
Paola Villanueva, Nigel W. Crawford, Mariana Garcia Croda, Simone Collopy, Bruno Araújo Jardim, Tyane de Almeida Pinto Jardim, Laurens Manning, Michaela Lucas, Helen Marshall, Cristina Prat-Aymerich, Alice Sawka, Ketaki Sharma, Darren Troeman, Ushma Wadia, Adilia Warris, Nicholas Wood, Nicole L. Messina, Nigel Curtis, Laure F. Pittet   +18 more
doaj   +1 more source

BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals

International Journal of Infectious Diseases, 2021
Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jeyadeepa, Nandhini Selvaraj, Dinesh Ashokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +1 more source

BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.

PLoS ONE, 2021
BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized.
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jayadeepa, Nandhini Selvaraj, Dinesh Asokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +2 more sources

BCG vaccination impact on mortality and recovery rates in COVID-19: A meta-analysis

Monaldi Archives for Chest Disease, 2021
COVID-19 is a pandemic caused by SARS-CoV-2 virus which is a very worrisome public health emergency. In this study, we compared the mortality rate and recovery rate in countries with and without BCG vaccination policy.
Surjit Singh, Daisy Khera, Ankita Chugh, Sameer Khasbage, Pushpinder S. Khera, Vinay Kumar Chugh   +5 more
doaj   +1 more source

Mapping BCG vaccination coverage in Ethiopia between 2000 and 2019

BMC Infectious Diseases, 2022
Introduction The Bacille-Calmette–Guerin (BCG) vaccination remains the primary strategy to prevent severe disseminated TB in young children, particularly in high TB-burden countries such as Ethiopia.
Kendalem Asmare Atalell, Mulat Asrade Alemayehu, Nahom Worku Teshager, Getaneh Mulualem Belay, Tewodros Getaneh Alemu, Degefaye Zelalem Anlay, Amare Wondim, Kefyalew Addis Alene   +7 more
doaj   +1 more source

Decreased Expression of CD314 by NK Cells Correlates with Their Ability to Respond by Producing IFN-γ after BCG Moscow Vaccination and Is Associated with Distinct Early Immune Responses

Vaccines, 2023
The immune response to vaccines is complex and results in various outcomes. BCG vaccination induces innate and specific responses that can lead to protection against tuberculosis, and cross-protection against other infections.
Adeliane Castro da Costa, Lília Cristina de Souza Barbosa, André Kipnis, Ana Paula Junqueira-Kipnis   +3 more
doaj   +1 more source

Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response. [PDF]

PLoS ONE, 2012
Oral delivery of BCG in a lipid formulation (Liporale™-BCG) targets delivery of viable bacilli to the mesenteric lymph nodes and confers protection against an aerosol Mycobacterium tuberculosis challenge.
Lindsay R Ancelet, Frank E Aldwell, Fenella J Rich, Joanna R Kirman   +3 more
doaj   +1 more source