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COMPARATIVE ANALYSIS OF THE FREQUENCY AND STRUCTURE OF COMPLICATIONS OF THE BCG AND BCG-M TUBERCULOSIS VACCINE

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2021
Introduction. The effectiveness of TB vaccination is low in more than half of children with tuberculosis, which is confirmed by the small size of the post-vaccination scar or its absence.
Pozdnyakova A. S.
doaj   +1 more source

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Cell Reports, 2020
Summary The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity ...
S. Moorlag, Y. A. Rodriguez-Rosales, J. Gillard, Stephanie Fanucchi, K. Theunissen, B. Novaković, C. D. de Bont, Yutaka Negishi, E. Fok, Lydia Kalafati, P. Verginis, V. Mourits, V. Koeken, L. D. de Bree, G. Pruijn, C. Fenwick, R. van Crevel, L. Joosten, I. Joosten, H. Koenen, Musa M. Mhlanga, D. Diavatopoulos, T. Chavakis, M. Netea   +23 more
semanticscholar   +1 more source

Protection against tuberculosis by Bacillus Calmette-Guérin (BCG) vaccination: A historical perspective.

i Medicina, 2021
Bacillus Calmette-Guérin (BCG) was developed exactly 100 years ago, and it is still the only licensed tuberculosis (TB) vaccine and the most frequently administered of all vaccines worldwide. Despite universal vaccination policies in TB-endemic settings,
T. Setiabudiawan, Remi K. Reurink, P. Hill, M. Netea, R. van Crevel, V. Koeken   +5 more
semanticscholar   +1 more source

Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?

Vaccine, 2021
Highlights • The BCG vaccine provides variable protection against tuberculosis.• Correlates of protection remain elusive, but IFNγ can measure immunogenicity.• BCG vaccination induces innate immune training as well as antigen-specific immunity.• Many ...
H. Dockrell, Egle Butkeviciute
semanticscholar   +1 more source

Tuberculin conversion rate after BCG vaccination of apparently healthy infants in a resource-poor setting

International Journal of Medicine and Health Development, 2022
Background: Although Bacillus Calmette Guerin (BCG) vaccine remains one of the most important public health preventive measures against tuberculosis (TB), the presence of a BCG scar may not imply an immune response.
Eziamaka J Enemuo, Kenechukwu Kosisochukwu Iloh, Agozie C Ubesie, Henrietta U Okafor, Anthony Nnaemeka Ikefuna   +4 more
doaj   +1 more source

Observational study to estimate the changes in the effectiveness of bacillus Calmette–Guérin (BCG) vaccination with time since vaccination for preventing tuberculosis in the UK

Health Technology Assessment, 2017
Background: Until recently, evidence that protection from the bacillus Calmette–Guérin (BCG) vaccination lasted beyond 10 years was limited. In the past few years, studies in Brazil and the USA (in Native Americans) have suggested that protection from ...
Punam Mangtani, Patrick Nguipdop-Djomo, Ruth H Keogh, Lucy Trinder, Peter G Smith, Paul EM Fine, Jonathan Sterne, Ibrahim Abubakar, Emilia Vynnycky, John Watson, David Elliman, Marc Lipman, Laura C Rodrigues   +12 more
doaj   +1 more source

COVID-19 and Beyond: Exploring Public Health Benefits from Non-Specific Effects of BCG Vaccination

Microorganisms, 2021
Bacille Calmette–Guérin (BCG) vaccination, widely used throughout the world to protect against infant tuberculous meningitis and miliary tuberculosis (TB), can provide broad non-specific protection against infectious respiratory diseases in certain ...
Kent J. Koster, Hilary L. Webb, Jeffrey D. Cirillo   +2 more
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Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19

Science Advances, 2020
National policies for universal BCG vaccination are associated with flattened growth of country-wise COVID-19 cases and deaths. Bacillus Calmette-Guérin (BCG) vaccination may reduce the risk of a range of infectious diseases, and if so, it could protect ...
Martha K. Berg, Qing-Gang Yu, Cristina E. Salvador, Irene Melani, S. Kitayama   +4 more
semanticscholar   +1 more source

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses

Immunity
SUMMARY While the Bacille-Calmette-Guérin (BCG) vaccine is used to prevent tuberculosis, it also offers protection against a diverse range of non-mycobacterial infections.
Sarah J. Sun, R. Aguirre-Gamboa, L. D. de Bree, J. Sanz, A. Dumaine, W. van der Velden, L. Joosten, S. Khader, Maziar Divangahi, M. Netea, Luis B. Barreiro   +10 more
semanticscholar   +1 more source

BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination

Science
Bacillus Calmette-Guérin (BCG) is a routinely used vaccine for protecting children against Mycobacterium tuberculosis that comprises attenuated Mycobacterium bovis. BCG can also be used to protect livestock against M.
A. Fromsa, Katriina Willgert, Sreenidhi Srinivasan, G. Mekonnen, Wegene Bedada, B. Gumi, M. Lakew, B. Tadesse, Berecha Bayissa, A. Sirak, Musse Girma Abdela, S. Gebre, T. Chibssa, Maroudam Veerasami, H. Vordermeier, Douwe Bakker, S. Berg, G. Ameni, N. Juleff, M. D. de Jong, J. Wood, A. Conlan, Vivek Kapur   +22 more
semanticscholar   +1 more source