Results 31 to 40 of about 806,785 (277)

BCG vaccination provides protection against IAV but not SARS-CoV-2

Cell Reports, 2022
Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch of our immune system.
E. Kaufmann, N. Khan, Kimvan Tran, Antigona Ulndreaj, Erwan Pernet, G. Fontes, Andréanne Lupien, P. Desmeules, F. McIntosh, Amina Abow, S. Moorlag, P. Debisarun, K. Mossman, A. Banerjee, D. Karo-Atar, Mina Sadeghi, S. Mubareka, D. Vinh, Irah L. King, C. Robbins, M. Behr, M. Netea, P. Joubert, M. Divangahi   +23 more
semanticscholar   +1 more source

Efficacy of BCG Vaccination Against Respiratory Tract Infections in Older Adults During the Coronavirus Disease 2019 Pandemic

Clinical Infectious Diseases, 2022
Background Older age is associated with increased severity and death from respiratory infections, including coronavirus disease 2019 (COVID-19). The tuberculosis BCG vaccine may provide heterologous protection against nontuberculous infections and has ...
S. Moorlag, Esther J. M. Taks, T. ten Doesschate, T. W. van der Vaart, A. Janssen, L. Müller, P. Ostermann, Helga Dijkstra, Heidi Lemmers, E. Simonetti, M. Mazur, H. Schaal, R. ter Heine, F. L. van de Veerdonk, C. Bleeker-Rovers, R. van Crevel, J. ten Oever, M. D. de Jonge, M. Bonten, C. V. van Werkhoven, M. Netea   +20 more
semanticscholar   +1 more source

Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response. [PDF]

PLoS ONE, 2012
Oral delivery of BCG in a lipid formulation (Liporale™-BCG) targets delivery of viable bacilli to the mesenteric lymph nodes and confers protection against an aerosol Mycobacterium tuberculosis challenge.
Lindsay R Ancelet, Frank E Aldwell, Fenella J Rich, Joanna R Kirman   +3 more
doaj   +1 more source

Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

Science Advances, 2022
Trained immunity describes the capacity of innate immune cells to develop heterologous memory in response to certain exogenous exposures. This phenomenon mediates, at least in part, the beneficial off-target effects of the BCG vaccine.
S. Bannister, Bowon Kim, Jorge Domínguez-Andrés, Gizem Kılıç, B. Ansell, M. Neeland, S. Moorlag, V. Matzaraki, A. Vlahos, R. Shepherd, S. Germano, M. Bahlo, N. Messina, R. Saffery, M. Netea, N. Curtis, B. Novaković   +16 more
semanticscholar   +1 more source

ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at Risk

Frontiers in Immunology, 2021
In a recent study of our group with the acronym ACTIVATE, Bacillus Calmete-Guérin (BCG) vaccination reduced the occurrence of new infections compared to placebo vaccination in the elderly. Most benefit was found for respiratory infections. The ACTIVATE-2
M. Tsilika, Esther J. M. Taks, Konstantinos Dolianitis, A. Kotsaki, K. Leventogiannis, Christina Damoulari, M. Kostoula, Maria Paneta, G. Adamis, I. Papanikolaou, K. Stamatelopoulos, Amalia Bolanou, K. Katsaros, Christina Delavinia, Ioannis Perdios, A. Pandi, K. Tsiakos, Nektarios Proios, Emmanouela Kalogianni, I. Delis, E. Skliros, K. Akinosoglou, Aggeliki Perdikouli, Garyfallia Poulakou, H. Milionis, E. Athanassopoulou, Eleftheria Kalpaki, Leda Efstratiou, Varvara Perraki, A. Papadopoulos, M. Netea, E. Giamarellos-Bourboulis   +31 more
semanticscholar   +1 more source

Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques

mBio, 2023
Alternative delivery routes of the current Mycobacterium tuberculosis (Mtb) vaccine, intradermally (ID) delivered BCG, may provide better protection against tuberculosis, and be more easily administered. Here, we use rhesus macaques to compare the airway
Stella G. Hoft, Keith D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Daniel F. Hoft, Richard Herbert, Daniel L. Barber   +7 more
doaj   +1 more source

BCG vaccination induces cross-protective immunity against pathogenic microorganisms.

Trends in immunology, 2022
Bacillus Calmette-Guérin (BCG) is an attenuated Mycobacterium bovis strain used as a vaccine to prevent Mycobacterium tuberculosis (M. tb) infection.
J. Soto, N. Gálvez, C. A. Andrade, Mario A. Ramírez, C. Riedel, A. Kalergis, S. Bueno   +6 more
semanticscholar   +1 more source

BCG vaccination potential for COVID-19: an analytical approach

Human Vaccines & Immunotherapeutics, 2021
In order to assess the possible protective potential of BCG vaccination as regards to COVID-19, we have analyzed BCG vaccination status and SARS CoV-2 morbidity and mortality in China and we have also examined other studies performed in other countries ...
Mina T. Kelleni
doaj   +1 more source

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

PLoS Biology, 2022
The antituberculosis vaccine Bacillus Calmette–Guérin (BCG) induces nonspecific protection against heterologous infections, at least partly through induction of innate immune memory (trained immunity).
V. Koeken, Cancan Qi, V. Mourits, L. D. de Bree, S. Moorlag, Vidhisha Sonawane, Heidi Lemmers, Helga Dijkstra, L. Joosten, A. van Laarhoven, Cheng-Jian Xu, R. van Crevel, M. Netea, Yang Li   +13 more
semanticscholar   +1 more source

Reactivation of BCG vaccination scars after vaccination with mRNA-Covid-vaccines: two case reports

BMC Infectious Diseases, 2021
Background From May 2020 to January 2021, we enrolled 1233 health care workers (HCW) from Danish Hospitals in a randomized trial evaluating whether Bacille Calmette-Guérin (BCG) provides protection against COVID-19.
Libin Mohamed, Anne Marie Rosendahl Madsen, Frederik Schaltz-Buchholzer, Anne Ostenfeld, Mihai G. Netea, Christine Stabell Benn, Poul-Erik Kofoed   +6 more
doaj   +1 more source