Results 41 to 50 of about 223,551 (298)

Synergistic impacts of rifampicin and doxorubicin against thioacetamide-induced hepatocellular carcinoma in rats

Liver Research, 2023
Background and aims: Combination therapy is a promising new strategy that has been proposed to increase the efficacy of cancer treatment. We aimed to investigate the anti-cancer activity of rifampicin monotherapy and its combination with doxorubicin ...
Zahraa R. Elshahawy, Entsar A. Saad, Rana R. El-Sadda   +2 more
doaj   +1 more source

Amifostine inhibits acrylamide-induced hepatotoxicity by inhibiting oxidative stress and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Acrylamide (ACR) is a toxic chemical agent that can induce hepatotoxicity through different mechanisms including oxidative stress and apoptosis. Amifostine is an important hepatoprotective and anti-oxidant compound.
Mostafa Karimi, Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Hossein Hosseinzadeh   +3 more
doaj   +1 more source

Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]

, 2017
Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
Berciano, Maria T., Calderó i Pardo, Jordi, Lafarga, Miguel, Narcís, Oriol J., Piedrafita Llorens, Lídia, Riancho, Javier, Tapia, Olga, Tarabal Mostazo, Olga   +7 more
core   +2 more sources

Effect of colony‐stimulating factor‐1 receptor overexpression on the growth of nasopharyngeal carcinoma xenografts in nude mice and its mechanism of action

Precision Radiation Oncology, 2020
Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj   +1 more source

How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]

, 2013
Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core   +2 more sources

Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H₂AX, CHK2 and p53

Cells, 2022
Herein, the apoptotic mechanism of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) was examined in cisplatin-resistant lung cancer cells. PGG significantly reduced viability; increased sub-G1 accumulation and the number of terminal deoxynucleotidyl ...
Ji-Hyun Kim, Eunji Im, Jihyun Lee, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Hyeon Hee Kwon, Bum Sang Shim, Bonglee Kim, Sung-Hoon Kim   +10 more
doaj   +1 more source

Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2020
Objective: Some previous studies have shown the protective effect of caffeine on apoptosis through the regulation of pro- and anti-apoptotic proteins.
Ali Zarghami Khameneh, Saeed Nikookheslat, Afshar Jafari , Pouran Karimi   +3 more
doaj   +1 more source

Antiapoptotic and antioxidative effects of cerium oxide nanoparticles on the testicular tissues of streptozotocin-induced diabetic rats: An experimental study

International Journal of Reproductive BioMedicine, 2021
Background: Cerium dioxide nanoparticles (CNPs) due to the antidiabetic and antioxidant activities are proposed for the treatment of oxidative stress-associated diseases.
Torab Solgi, Iraj Amiri, Sara Soleimani Asl, Massoud Saidijam, Banafsheh Mirzaei Seresht, Tayebe Artimani   +5 more
doaj   +1 more source

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

Reproductive status of male rat offspring following exposure to methamphetamine during intrauterine life: An experimental study

International Journal of Reproductive BioMedicine, 2023
Background: Methamphetamine abuse during pregnancy is associated with maternal and fetal adverse outcomes. Methamphetamine induces reproductive damage in adults; however, its effect has not been studied during pregnancy.
Zahra Khoshgoftar Some Saraii, Soroush Dianaty, Fatemeh Rouhollah, Nayereh Zare, Batool Ghorbani Yekta   +4 more
doaj   +1 more source