Frontiers in Pharmacology, 2019 Bcl-2 family protein is an important factor in regulating apoptosis and is associated with cancer. The anti-apoptotic proteins of Bcl-2 family, such as Bcl-2, are overexpression in numerous tumors, and contribute to cancer formation, development, and ...
Mei Wen +12 more
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Reaction of Bcl-2+ cells of the parietal lobe cortex of rats with experimental diabetes mellitus to ischemia-reperfusion [PDF]
, 2016 The peculiarities of anti-apoptotic mechanisms in the nerve and glial cells of the parietal lobe cortex are studied by the density changes of Bcl-2+-cells location and concentration of Bcl-2 protein in them in rats with diabetes mellitus in the dynamics ...
Boychuk, T.M., Kmet, T.I., Tkachuk, S.S.
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Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]
, 2016 The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh +14 more
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Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling
Advanced Science, EarlyView.This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu +6 more
wiley +1 more source
Egyptian Journal of Medical Human GeneticsApoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases.
Md. Saddam +7 more
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Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. [PDF]
, 1987 W. Graninger +4 more
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Advanced Science, EarlyView.A novel biodegradable wound dressing (E‐PCLs) based on polycaprolactone (PCL) and an enzyme complex (RHP‐BCL) is developed using a fiber microfluidic electrospinning technique. The dressing achieves complete degradation within 14 days, eliminates microplastic residues, and promotes scar‐free healing (99% in 21 days).
Lingling Fan +7 more
wiley +1 more source
Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation [PDF]
, 2018 Using multicistronic expression technology we generated a stable Chinese hamster ovary (CHO) cell line (MG12) expressing a model secreted heterologous glycoprotein, the secreted form of the human placental alkaline phosphatase (SEAP), and bcl-2, best ...
Bailey, James +6 more
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Simultaneous presentation of T- and B-cell malignant lymphoma with bcl- 2 gene involvement [PDF]
, 1989 FE Cotter, PA Hall, BD Young, TA Lister
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Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition
Advanced Science, EarlyView.Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu +12 more
wiley +1 more source