Results 251 to 260 of about 21,951,536 (341)

Antitumor and Cytogenotoxic Activities of Libidibia ferrea Hydroalcoholic Extracts in Murine Breast Carcinoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Breast cancer is the most prevalent cancer type among women worldwide, and there is a critical need for more effective and safer treatments, especially for aggressive and therapy‐resistant subtypes. Libidibia ferrea, a native plant from Brazil, exhibits anti‐inflammatory, antimicrobial, antioxidant, and antitumor properties.
Diego Pereira de Menezes, Evaldo dos Santos Monção Filho, Atanara Alves de Sousa, João Pedro Alves Damasceno do Lago, Karla Darlianny Mourão Cavalcante, Fernanda Alves de Sousa Cavalcante, Irismara Sousa Silva, Marina Pinto Sanches, Semiramis Jamil Hadad do Monte, Ester Miranda Pereira, Paulo Michel Pinheiro Ferreira, Joao Marcelo de Castro e Sousa, Gerardo Magela Vieira Júnior, Dalton Dittz   +13 more
wiley   +1 more source

BCL-2 inhibitors in hematological malignancies: biomarkers that predict response and management strategies. [PDF]

Front Oncol
Markouli M, Pagoni MN, Diamantopoulos P.
europepmc   +1 more source

Cytotoxic Activity of Opopanax hispidus (Friv.) Griseb.: Characterization of a New Chalcone‐type Compound

Chemistry &Biodiversity, EarlyView.
ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban, İpek Süntar, Perihan Gürbüz, Esra Emerce, Osman Tugay, Şengül Dilem Doğan, Beyza Hamur, Ahmet Ceyhan Gören   +7 more
wiley   +1 more source

Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway. [PDF]

Cancer Med
Li X, Hua D, Wu D, Hong W, Kang Y, Tang L, Yang Q, Wang X, Li B, Li R, Chen Z, Cui G.   +11 more
europepmc   +1 more source

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

, 1995
Tadaaki Miyazaki, Zhao‐Jun Liu, Atsuo Kawahara, Yasuhiro Minami, Kyoko Yamada, Yoshihide Tsujimoto, Edward L. Barsoumian, Roger M Perlmutter, Tadatsugu Taniguchi   +8 more
openalex   +1 more source

Selective Lysine Ubiquitination Using Activated Phenol Esters

ChemBioChem, EarlyView.
Ubiquitination of both peptides and proteins using a novel water‐soluble acylation reagent, based on a 2,4‐dichloro‐6‐sulfonic acid phenol ester, is presented. At alkaline pH, fast lysine ubiquitination is observed on model peptide FLYRANK, and its regioselectivity is confirmed using controls.
Halana C. Vlaming, Yara Huppelschoten, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Francesca D’Amico, Kim B. Jensen, Jens Buchardt, Thomas E. Nielsen, Bhavesh Premdjee, Gerbrand J. van der Heden van Noort   +9 more
wiley   +1 more source

Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function. [PDF]

Biomedicines
Perez-Serna AA, Guzman-Llorens D, Dos Santos RS, Marroqui L.   +3 more
europepmc   +1 more source

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

, 1997
Brian S. Chang, Andy J. Minn, Steven W. Muchmore, Stephen W. Fesik, Craig B. Thompson   +4 more
openalex   +1 more source

Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways

ChemMedChem, Accepted Article.
Continuing our research aimed at discovering new BAG3 modulators as attractive anticancer drug candidates, we performed a screening campaign on an in‐house library, including compounds featuring a large variety of scaffolds. The obtained results induced us to focus on the triazole moiety and, following a stepwise structural refinement of the scaffold ...
Dafne Ruggiero, Eleonora Boccia, Emis Ingenito, Vincenzo Vestuto, Gilda D’Urso, Alessandra Capuano, Agostino Casapullo, Stefania Terracciano, Giuseppe Bifulco, Gianluigi Lauro, Ines Bruno   +10 more
wiley   +1 more source

Synthesis and Biological Evaluation of Quercetagetin Derivatives as the Inhibitors of Mcl-1 and Bcl-2 Against Leukemia. [PDF]

Int J Mol Sci
Li K, Ge X, Liu W, Huang L, Lv X, Tang Y, He Z, Yang Y, Chen M, Zeng J, Cheng P.   +10 more
europepmc   +1 more source