Results 41 to 50 of about 231,126 (194)
Haematologica, 2020 The BCL-2-specific inhibitor, ABT-199 (venetoclax) has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast, responses are usually much less in diffuse large B-cell lymphoma (DLBCL), despite high level ...
Victoria M. Smith +11 more
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Bcl-XL but Not Bcl-2 Is a Potential Target in Medulloblastoma Therapy
Pharmaceuticals, 2022 Medulloblastoma (MB) is the most common solid tumour in children and, despite current treatment with a rather aggressive combination therapy, accounts for 10% of all deaths associated with paediatric cancer.
Mike-Andrew Westhoff +10 more
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IMMUNOHISTOCHEMICAL EXPRESSION OF p53 AND BCL-2 PROTEINS IN ADVANCED ESOPHAGEAL CANCER PATIENTS [PDF]
Acta Medica Iranica, 2005 The current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. We studied the p53 and Bcl-2 protein expression in esophageal carcinomas to correlate
S. Arbabi Bidgoli +4 more
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PLoS ONE, 2012 MDA-7/IL-24 was involved in the specific cancer apoptosis through suppression of Bcl-2 expression, which is a key apoptosis regulatory protein of the mitochondrial death pathway. However, the underlying mechanisms of this regulation are unclear.
Hui Tian +8 more
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The Effect of T69E-mimicked Phosphorylation on the Interaction Between Bcl-2 and Nur77
Chinese Journal of Magnetic Resonance, 2022 Bcl-2 mainly executes anti-apoptotic function in the Bcl-2 family. Nuclear orphan receptor Nur77 can be translocated from nucleus to mitochondria, then interact with Bcl-2 to reverse the function of Bcl-2 from a cell protector to a cell killer, thereby ...
Qian XU +5 more
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Haematologica, 2008 Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi +9 more
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Bcl-2 family proteins and mitochondria
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 The Bcl-2 family of proteins plays a pivotal role in regulating cell life and death. Many of these proteins reside in the outer mitochondrial membrane, oriented towards the cytosol. Cytoprotective Bcl-2 family proteins such as Bcl-2 and Bcl-XL prevent mitochondrial permeability transition pore opening and release of apoptogenic proteins from ...
Reed, John C. +2 more
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Mechanisms of Bcl-2 protein function.
Histology and histopathology, 1998 The Bcl-2 protein blocks a distal step in an evolutionarily conserved pathway for programmed cell death and apoptosis. The gene encoding this protein was first discovered because of its involvement in the t(14;18) chromosomal translocations commonly found in B-cell lymphomas. Overexpression of Bcl-2 also occurs in many other types of human cancers, and
Wang, H.G., Reed, J.C.
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Cancer Biology & Medicine, 2013 Objective:B-cell lymphoma 2 (Bcl-2) is an important member of the Bcl-2 family of proteins that regulate the induction of apoptosis. This study aims to investigate whether Bcl-2 small interfering RNA (siRNA) combined with miR-15a oligonucleotides (ODN ...
Li Ding +6 more
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Breast Cancer Research, 2020 Background Targeted therapies for triple-negative breast cancer (TNBC) are limited; however, the epidermal growth factor receptor (EGFR) represents a potential target, as the majority of TNBC express EGFR. The purpose of these studies was to evaluate the
Jason J. Zoeller +13 more
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