Results 61 to 70 of about 21,951,437 (242)
Bcl-2 Expression in Pericytes and Astrocytes Impacts Vascular Development and Homeostasis
Scientific Reports, 2019 B-cell lymphoma 2 (Bcl-2) protein is the founding member of a group of proteins known to modulate apoptosis. Its discovery set the stage for identification of family members with either pro- or anti-apoptotic properties.
Ismail S. Zaitoun +10 more
doaj +1 more source
BMC Cancer, 2019 Bcl-2 family members play an important role in the development of malignant lymphoma and can induce drug resistance in anticancer treatment. The development of small molecules targeting Bcl-2 family proteins may be a new strategy for the treatment of ...
Yue-li Sun +6 more
semanticscholar +1 more source
Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles
Journal of Functional Biomaterials, 2014 Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense anti ...
Yen-Ling Lin +4 more
doaj +1 more source
Targeting the Bcl-2 Family in B Cell Lymphoma
Frontiers in Oncology, 2019 Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma subtypes share a set of underlying traits that promote the development and sustain malignant B cells.
Clare M. Adams +3 more
semanticscholar +1 more source
Cancer Biology & Medicine, 2013 Objective:B-cell lymphoma 2 (Bcl-2) is an important member of the Bcl-2 family of proteins that regulate the induction of apoptosis. This study aims to investigate whether Bcl-2 small interfering RNA (siRNA) combined with miR-15a oligonucleotides (ODN ...
Li Ding +6 more
doaj +1 more source
Breast Cancer Research, 2020 Background Targeted therapies for triple-negative breast cancer (TNBC) are limited; however, the epidermal growth factor receptor (EGFR) represents a potential target, as the majority of TNBC express EGFR. The purpose of these studies was to evaluate the
Jason J. Zoeller +13 more
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BCL-2 as therapeutic target for hematological malignancies
Journal of Hematology & Oncology, 2018 Disruption of the physiologic balance between cell proliferation and cell death is an important step of cancer development. Increased resistance to apoptosis is a key oncogenic mechanism in several hematological malignancies and, in many cases ...
G. Perini +4 more
semanticscholar +1 more source
Hair Follicle Apoptosis and Bcl-2
Journal of Investigative Dermatology Symposium Proceedings, 1999 Hair follicle (HF) morphogenesis and cycling are characterized by a tightly controlled balance of proliferation, differentiation and apoptosis. The members of the bcl-2 family of proto-oncogenes are important key players in the apoptosis control machinery of most cell types.
Ralf Paus +9 more
openaire +3 more sources
Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins
Front. Cell Dev. Biol., 2018 Bcl-2 family proteins are recognized as major regulators of the mitochondrial pathway of apoptosis. They control the mitochondrial outer membrane permeabilization (MOMP) by directly localizing to this organelle.
N. Popgeorgiev, Lea Jabbour, G. Gillet
semanticscholar +1 more source
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis
Cell Reports, 2017 Summary: We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked ...
Natalia Edison +11 more
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