Results 71 to 80 of about 21,951,437 (242)

BCL-2 inhibition in AML: an unexpected bonus?

Blood, 2018
B-cell lymphoma 2 (BCL-2) was discovered at the breakpoint of the t(14;18) in follicular lymphoma >30 years ago. Although inhibition of BCL-2 first proved valuable in lymphoid malignancies, clinical progress in myeloid malignancies lagged.
M. Konopleva, A. Letai
semanticscholar   +1 more source

Exploring the Conformational Space of Bcl-2 Protein Variants: Dynamic Contributions of the Flexible Loop Domain and Transmembrane Region

Molecules, 2019
Members of the Bcl-2 protein family regulate apoptosis through interactions with several proteins. A critical intrinsically disordered region (IDR) present in some members of the Bcl-2 family is essential for their function.
Luis A. Caro-Gómez, Jorge L. Rosas-Trigueros, Edgar Mixcoha, José L. Vique-Sánchez, Humberto Gasperin-Sánchez, Claudia G. Benítez-Cardoza, Absalom Zamorano-Carillo   +6 more
doaj   +1 more source

Familija Bcl 2 proteina kod malignih bolesti [PDF]

Vojnosanitetski Pregled, 2004
Brajušković Goran R., Milić-Škaro Anđelija, Cerović Snežana J., Marjanović Slobodan A., Ušaj-Knežević Slavica, Čizmić Milica, Dimitrijević Jovan   +6 more
doaj   +1 more source

MOMP, cell suicide as a BCL-2 family business

Cell Death and Differentiation, 2017
Apoptosis shapes development and differentiation, has a key role in tissue homeostasis, and is deregulated in cancer. In most cases, successful apoptosis is triggered by mitochondrial outer membrane permeabilization (MOMP), which defines the ...
H. Kalkavan, D. Green
semanticscholar   +1 more source

The Molecular Perspective: Bcl-2 and Apoptosis

The Oncologist, 2002
Abstract Learning Objective After completing this course, the reader will be able to: Gain a basic understanding of the structure and function of the bcl-2 family of proteins, and their place in apoptosis and cancer.
openaire   +4 more sources

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.

PLoS ONE, 2013
The anti-apoptotic Bcl-2 protein is the founding member and namesake of the Bcl-2-protein family. It has recently been demonstrated that Bcl-2, apart from its anti-apoptotic role at mitochondrial membranes, can also directly interact with the inositol 1 ...
Giovanni Monaco, Elke Decrock, Koen Nuyts, Larry E Wagner, Tomas Luyten, Sergei V Strelkov, Ludwig Missiaen, Wim M De Borggraeve, Luc Leybaert, David I Yule, Humbert De Smedt, Jan B Parys, Geert Bultynck   +12 more
doaj   +1 more source

A comparative analysis of BCL-2 family [PDF]

Bioinformation, 2019
The BCL-2 family is conserved in evolution and shares a BCL-2 homology domain. It promotes and inhibits apoptosis. It is also known that apoptosis has a major role in effective cancer treatment. Therefore, it is of interest to document information related to the BCL-2 family of proteins for analysis by prediction tools.
openaire   +2 more sources

Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy

Nature Communications
Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved selective BCL-2 inhibitor. However, its application has led to an emergence of
Fengwei Li, Junjie Liu, Chao Liu, Ziyan Liu, Xiangda Peng, Yinyue Huang, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen, Dan Xiong, Xiaotong Diao, Sheng Wang, Jingjing Zhuang, Chuanliu Wu, Dalei Wu   +15 more
doaj   +1 more source

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

BMC Cancer, 2006
Background Bcl-2 and Bcl-XL are anti-apoptotic paralogues that inhibit apoptosis elicited by a wide variety of stimuli, and play critical roles in cancer development and resistance to treatment.
Leber Brian, Hollerbach Catherine, Zhu Weijia, Fiebig Aline A, Andrews David W   +4 more
doaj   +1 more source

The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Cell Death and Differentiation, 2017
Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven
Jerry M. Adams, S. Cory
semanticscholar   +1 more source