Results 11 to 20 of about 153,102 (279)
ΔN-Bcl-xL, a therapeutic target for neuroprotection
Neural Regeneration Research, 2017 The B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial anti-apoptotic protein that plays a role in neuroprotection. However, during excitotoxic stimulation, Bcl-xL undergoes caspase-dependent cleavage and produces a fragmented form, ΔN-Bcl-xL ...
Han-A Park, Elizabeth A Jonas
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Bcl-xL: A Focus on Melanoma Pathobiology
International Journal of Molecular Sciences, 2021 Apoptosis is the main mechanism by which multicellular organisms eliminate damaged or unwanted cells. To regulate this process, a balance between pro-survival and pro-apoptotic proteins is necessary in order to avoid impaired apoptosis, which is the ...
Anna Maria Lucianò +3 more
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Neoplasia: An International Journal for Oncology Research, 1999 Bcl-2 and Bcl-XL belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation.
Alnawaz Rehemtulla +6 more
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The Structural Biology of Bcl-xL [PDF]
International Journal of Molecular Sciences, 2019 Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on
W. Douglas Fairlie +3 more
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Bcl-xl expression in multiple myeloma
Medical Oncology, 2005 In the present study the immunohistochemical expression of Bcl-xl, a downstream target of the IL-6-controlled signal transducer and activator of transcription-3 (Stat3) was studied in 40 multiple myeloma (MM) cases before treatment and 11 MM patients at ...
Vellenga, E +3 more
core +6 more sources
Nutritional Regulators of Bcl-xL in the Brain [PDF]
Molecules, 2018 B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic Bcl-2 protein found in the mitochondrial membrane. Bcl-xL is reported to support normal brain development and protects neurons against toxic stimulation during pathological process via its roles ...
Han-A Park +4 more
doaj +3 more sources
Bcl-xL as a Modulator of Senescence and Aging [PDF]
International Journal of Molecular Sciences, 2021 Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that.
Cristina Mas-Bargues +2 more
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Bcl-xL in neuroprotection and plasticity [PDF]
Frontiers in Physiology, 2014 Accepted features of neurodegenerative disease include mitochondrial and protein folding dysfunction and activation of pro-death factors. Neurons that experience high metabolic demand or those found in organisms with genetic mutations in proteins that control cell stress may be more susceptible to aging and neurodegenerative disease. In neurons, events
Jonas, EA, Porter, GA, Alavian, KN
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Advances in Bcl-xL Research 2.0
International Journal of Molecular Sciences, 2023 Apoptosis is a form of programmed cell death that is highly conserved in metazoan organisms, where it ensures the proper development and homeostasis of tissues [...]
Joann Kervadec, Muriel Priault
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Conformational states of the cytoprotective protein Bcl-xL [PDF]
Biophysical Journal, 2020 ABSTRACT Bcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anti-cancer therapy and for studies aimed at understanding its structure and activity.
Ryzhov, P. +5 more
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