Results 21 to 30 of about 153,102 (279)
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]
PLoS ONE, 2010 Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault +5 more
doaj +1 more source
Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
iScience, 2023 Summary: Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive lymphoid malignancy with a poor prognosis and lacks standard treatment. Targeted therapies are urgently needed.
Chuanxu Liu +15 more
doaj +1 more source
The Role of Bcl-xL Protein in Viral Infections [PDF]
International Journal of Molecular Sciences, 2021 Bcl-xL represents a family of proteins responsible for the regulation of the intrinsic apoptosis pathway. Due to its anti-apoptotic activity, Bcl-xL co-determines the viability of various virally infected cells. Their survival may determine the effectiveness of viral replication and spread, dynamics of systemic infection, and viral pathogenesis.
Zbigniew Wyżewski +3 more
openaire +2 more sources
Involvement of Bcl-xL in Neuronal Function and Development [PDF]
International Journal of Molecular Sciences, 2021 The B-cell lymphoma (Bcl-2) family of proteins are mainly known for their role in the regulation of apoptosis by preventing pore formation at the mitochondrial outer membrane and subsequent caspase activation. However, Bcl-2 proteins also have non-canonical functions, independent of apoptosis. Indeed, the cell death machinery, including Bcl-2 homologs,
Julie Bas, Trang Nguyen, Germain Gillet
openaire +2 more sources
Bad expression influences time to androgen escape in prostate cancer [PDF]
, 2007 <b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Teo, K. +4 more
core +1 more source
Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage [PDF]
Cell Death Discovery, 2016 AbstractCisplatin is a widely used chemotherapeutic agent, yet its efficacy is limited by nephrotoxicity. The severity of nephrotoxicity is associated with the extent of kidney cell death. Previously, we found that cisplatin-induced kidney cell death was dependent on Cdk2 activation, and inhibition of Cdk2 protected cells from cisplatin-induced ...
Seng, NS +3 more
openaire +2 more sources
Roles and Regulation of BCL-xL in Hematological Malignancies [PDF]
International Journal of Molecular Sciences, 2022 Members of the Bcl-2 family are proteins that play an essential role in the regulation of apoptosis, a crucial process in development and normal physiology in multicellular organisms. The essential mechanism of this family of proteins is given by the role of pro-survival proteins, which inhibit apoptosis by their direct binding with their counterpart ...
Mario Morales-Martínez, Mario I. Vega
openaire +3 more sources
PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors
Exploration of Targeted Anti-tumor Therapy, 2020 BCL-XL is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance.
Peiyi Zhang +5 more
doaj +1 more source
Bcl-xL Inhibitor ABT-737 Reveals a Dual Role for Bcl-xL in Synaptic Transmission [PDF]
Journal of Neurophysiology, 2008 A role for BCL-xL in regulating neuronal activity is suggested by its dramatic effects on synaptic function and mitochondrial channel activity. When recombinant BCL-xL is injected into the giant presynaptic terminal of squid stellate ganglion or applied directly to mitochondrial outer membranes within the living terminal, it potentiates synaptic ...
John A, Hickman +3 more
openaire +2 more sources
Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL
Neoplasia: An International Journal for Oncology Research, 2001 Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-XL compared with ...
Raj. S. Mitra +6 more
doaj +1 more source