Results 41 to 50 of about 153,102 (279)
Biomolecules, 2023 The antiapoptotic protein Bcl-xL is a major regulator of cell death and survival, but many aspects of its functions remain elusive. It is mostly localized in the mitochondrial outer membrane (MOM) owing to its C-terminal hydrophobic α-helix.
Akandé Rouchidane Eyitayo +4 more
doaj +1 more source
Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]
, 2013 Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
Yong J. Lee +16 more
core +1 more source
Bcl-xL is required for the survival of KSHV latently infected endothelial cells.
, 2023 (A) Western blot analysis with an antibody to Bcl-xL in TIME cells treated with sgRNAs targeting Bcl-xL or a non-targeting control (NTC) sgRNA. (B) TIME cells transduced with the indicated sgRNAs were mock or KSHV infected for 48 hours and cell viability
Michael Lagunoff (143637) +4 more
core +1 more source
Journal of Pharmacy and Bioallied Sciences, 2020 The naturally derived flavonoids are well known to have anticarcinogenic effects. Flavonoids could be an alternative strategy for ovarian cancer treatment, due to existing platinum-based drugs are reported to develop resistance with low survival rates ...
Mohd Faiz Abd Ghani +2 more
doaj +1 more source
Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL [PDF]
, 2016 The heterologous expression of Bax, and other Bcl-2 family members, in the yeast Saccharomyces cerevisiae, has proved to be a valuable reporter system to investigate the molecular mechanisms underlying their interaction with mitochondria.
Garenne, D. +8 more
core +1 more source
Impact of deamidation on the structure and function of anti-apoptotic Bcl-xL.
, 2021 Bcl-xL is an anti-apoptotic mitochondrial trans-membrane protein, known to play a crucial role in the survival of tumor cells. The deamidation of Bcl-xL is a pivotal switch that regulates its biological function.
Saron, Catak +2 more
core +1 more source
Conformation of BCL-XL upon Membrane Integration [PDF]
Journal of Molecular Biology, 2015 BCL-XL is an anti-apoptotic BCL-2 family protein found both in the cytosol and bound to intracellular membranes. Structural studies of BCL-XL have advanced by deleting its hydrophobic C-terminus and adding detergents to enhance solubility. However, since the C-terminus is essential for function and detergents strongly affect structure and activity, the
Yong Yao +6 more
openaire +2 more sources
Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML.
BloodAcute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN) is known as post-MPN AML. Current treatments don't significantly extend survival beyond 12 months. BCL-xL has been found to be overexpressed in leucocytes from MPN patients,
Wang Z +23 more
europepmc +2 more sources
BCL-XL is an actionable target for treatment of malignant pleural mesothelioma
, 2020 © 2020, The Author(s). Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural mesothelioma (MPM) in over a decade.
Surein Arulananda (9474620) +17 more
core +1 more source
Control of cellular Bcl-xL levels by deamidation-regulated degradation. [PDF]
PLoS Biology, 2013 The cellular concentration of Bcl-xL is among the most important determinants of treatment response and overall prognosis in a broad range of tumors as well as an important determinant of the cellular response to several forms of tissue injury.
So Hee Dho +8 more
doaj +1 more source