Results 51 to 60 of about 153,102 (279)
, 2023 (A) TIME cells were transduced with the indicated sgRNAs and selected as before and were subsequently mock or KSHV infected. Cell viability was measured with a trypan blue assay 48 hpi.
Michael Lagunoff (143637) +4 more
core +1 more source
PLoS ONE, 2010 Increased expression of Bcl-xL in cancer has been shown to confer resistance to a broad range of apoptotic stimuli and to modulate a number of other aspects of cellular physiology, including energy metabolism, cell cycle, autophagy, mitochondrial fission/
Maria Teresa Vento +6 more
doaj +1 more source
Bcl-xL is not required for survival during latent infection in other cell types.
, 2023 (A) BCBL-1, cells were transduced with sgRNAs selected for using puromycin resistance for 4 days, then seeded at 1 x 105 cells/mL. Cell viability was measured using a trypan blue assay at 24, 48, 72, and 96 h post seeding. (B) BCBL-1 cells were seeded at
Michael Lagunoff (143637) +4 more
core +1 more source
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas [PDF]
Journal of Hematology & Oncology, 2020 Abstract Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TCL cell lines, patient-derived xenografts (PDXs), and primary patient samples depend on Bcl-xL for survival.
Yonghan He +15 more
openaire +4 more sources
Haematologica, 2023 BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-XL and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCLX L/BCL-2 ...
Yannan Jia +19 more
doaj +1 more source
The Effects of Thymoquinone on Viability, and Anti-apoptotic Factors (BCL-XL, BCL-2, MCL-1) in Prostate Cancer (PC3) Cells: An In Vitro and Computer-Simulated Environment Study [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Since active plant ingredients can induce apoptosis in many tumors, in this study we evaluate the apoptotic effects of thymoquinone (TQ) on PC3 cells.
Javad Saffari_Chaleshtori +3 more
doaj +1 more source
Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. [PDF]
PLoS ONE, 2013 Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis.
Bruno Christian Koehler +9 more
doaj +1 more source
Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members.
, 2013 Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is an open question.
Ali Hosseini (383134) +26 more
core +1 more source
Bcl-XL: A multifunctional anti-apoptotic protein
Pharmacological Research, 2020 B-cell lymphoma-extra large (Bcl-XL) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. Bcl-XL is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-XL is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects.
Mingxue, Li +4 more
openaire +2 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source