Results 221 to 230 of about 91,646 (261)
Phosphorylation of Bcl2 and regulation of apoptosis [PDF]
Leukemia, 2001 Members of the Bcl2 family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg Bcl2, Bcl-XL) or promote (eg Bax, Bad) apoptosis. While the mechanism(s) of Bcl2's anti-apoptotic function is not yet clear, introduction of Bcl2 into most eukaryotic cell types will protect the recipient cell ...
P P Ruvolo, W Stratford May, Deng X
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Genes, Chromosomes and Cancer, 1991
AbstractWe report a new class of molecular lesions in the 5′ region of the BCL2 protooncogene when it undergoes a t(14;18) translocation‐associated rearrangement in the major break cluster (MBR) or minor break cluster (MCR) regions. Among 52 tumors assayed for BCL2 rearrangements using the MBR, MCR, and 5′ probes, seven (six with MBR and one with MCR ...
V, Mikraki, M, Ladanyi, R S, Chaganti
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AbstractWe report a new class of molecular lesions in the 5′ region of the BCL2 protooncogene when it undergoes a t(14;18) translocation‐associated rearrangement in the major break cluster (MBR) or minor break cluster (MCR) regions. Among 52 tumors assayed for BCL2 rearrangements using the MBR, MCR, and 5′ probes, seven (six with MBR and one with MCR ...
V, Mikraki, M, Ladanyi, R S, Chaganti
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BCL2A1: the underdog in the BCL2 family [PDF]
Cell Death and Differentiation, 2011 B-cell lymphoma 2 (BCL2) proteins are important cell death regulators, whose main function is to control the release of cytochrome c from mitochondria in the intrinsic apoptotic pathway. They comprise both pro- and anti-apoptotic proteins, which interact in various ways to induce or prevent pore formation in the outer mitochondrial membrane.
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Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction
Biochemical Pharmacology, 2017Apoptosis is a highly regulated pathway of programmed cell death relying on the fine balance between pro and antiapoptotic binding partners. Overexpression of the antiapoptotic protein BCL2 in several cancers makes it an ideal target for chemotherapy, with minimum side effects.
Supriya V, Vartak +11 more
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1995
Abstract Probes for the IgH locus were used to clone t(14; 18) breakpoint DNAs. These DNAs allowed the identification of a transcriptional unit on chromosome 18, which was named bc!2. The bcl2 gene is transcribed by alternative splicing into three mRNAs of different sizes.
James R Bischoff +1 more
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Abstract Probes for the IgH locus were used to clone t(14; 18) breakpoint DNAs. These DNAs allowed the identification of a transcriptional unit on chromosome 18, which was named bc!2. The bcl2 gene is transcribed by alternative splicing into three mRNAs of different sizes.
James R Bischoff +1 more
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Enhancing dendritic cells by inhibiting BCL2
Trends in Cancer, 2023Dendritic cells play an important role in anticancer immunity by exposing T cells to tumor-associated antigens. In a recent study, Zhao et al. show that BCL2 inhibition improves the ability of dendritic cells to present antigen to T cells and activate their antitumor cytotoxicity.
Christopher A G, Booth, Andrew A, Lane
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2008
The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53).
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The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53).
openaire +3 more sources
BCL2: A promising cancer therapeutic target
Biochimica Et Biophysica Acta: Reviews on Cancer, 2017A remarkable characteristic of majority of cancer cells is that, they fail to undergo apoptosis, which in turn confers them a survival advantage over normal cells. Targeted cancer therapy aims at disrupting the functions of proteins that play an important role during cancer progression.
Sathees C Raghavan
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