Results 21 to 30 of about 288,388 (279)

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne, Falkenburg, J. H. Frederik, Liebermann, Marcus, Nijmeijer, Bart A., Ottmann, Oliver Gerhard, Pfeifer, Heike, Ruthardt, Martin, Tesanovic, Tamara, Wystub, Sylvia   +8 more
core   +7 more sources

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation [PDF]

, 2007
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1).
Ben J. C. Quah, Christopher R. Parish, Klaus I. Matthaei, Mark D. Hulett, Vaughan P. Barlow, Virginia McPhun   +5 more
core   +2 more sources

Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL [PDF]

Blood, 1993
Abstract It is well established that the chimeric BCR-ABL gene formed by joining parts of the BCR and ABL genes plays a key role in the pathogenesis of Philadelphia (Ph) chromosome-positive leukemias. We report that simultaneous expression of P210 BCR-ABL and P160 BCR in simian COS-1 cells yielded stable complexes of these two proteins ...
D, Lu, J, Liu, M, Campbell, J Q, Guo, N, Heisterkamp, J, Groffen, E, Canaani, R, Arlinghaus   +7 more
openaire   +3 more sources

Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas

Forum of Clinical Oncology, 2017
In normal B-cells, Bruton tyrosine kinase (Btk), a non-receptor tyrosine kinase involved in B-cell receptor (BCR) signalling, is essential for cell survival and maturation. Not surprisingly, Btk is also implicated in the pathogenesis of B-cell lymphomas,
Sklavenitis-Pistofidis R., Koletsa T., Lazaridou A., Goulas A.   +3 more
doaj   +1 more source

Management of imatinib-resistant CML patients [PDF]

, 2007
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option.
Branford S, Burger H, Burgess MR, Cortes J, Crossman LC, Donato NJ, Druker BJ, Gambacorti-Passerini C, Giles F, Hochhaus A, Hughes TP, Iacobucci I, Kantarjian H, Lahaye T, Mahon FX, Melo JV, O'Hare T, Quintas-Cardama A, Rousselot P, Sleijfer S, Soverini S, Weisberg E   +21 more
core   +1 more source

Studi Daya Dukung Pondasi Dangkal pada Tanah Gambut dengan Kombinasi Geotekstil dan Grid Bambu

Jurnal Teknik Sipil, 2011
Pembangunan konstruksi di atas tanah gambut mempunyai banyak masalah, diantaranya adalah daya dukung tanah yang rendah dan penurunan yang besar. Penggunaan kombinasi grid bambu dan geotekstil diharapkan akan dapat mengatasi masalah tersebut.
Soewignjo Agus Nugroho
doaj   +1 more source

MTSS1 is a critical epigenetically regulated tumor suppressor in CML [PDF]

, 2015
Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr ...
Braunschweig, T., Brümmendorf, T. H., Chatain, N., Copland, M., Costa, I. G., Gusmao, E. G., Haenzelmann, S., Hamilton, A., Helgason, G.V., Herrmann, O., Holyoake, T. L., Kintsler, S., Koschmieder, S., Li, S., Merle Reher, M., Müller-Tidow, C., Schemionek, M., Schubert, C., Schwab, A.   +18 more
core   +1 more source

Rapid and Cost-effective Embryo Culture Technique for Commercial Production of Makapuno Seedlings

CORD, 2011
An embryo cultured Makapuno (ECM) production scheme which is simpler, faster and more low-cost than the current protocol has been developed. With improvements in the ex vitro establishment environment, the cut-off age for in vitro stage of seedlings ...
Osmundo D. Orense
doaj   +1 more source

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Frontiers in Pharmacology, 2021
Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes.
Michele Massimino, Michele Massimino, Elena Tirrò, Elena Tirrò, Stefania Stella, Stefania Stella, Livia Manzella, Livia Manzella, Maria Stella Pennisi, Maria Stella Pennisi, Chiara Romano, Chiara Romano, Silvia Rita Vitale, Silvia Rita Vitale, Adriana Puma, Adriana Puma, Cristina Tomarchio, Cristina Tomarchio, Sandra Di Gregorio, Sandra Di Gregorio, Agostino Antolino, Francesco Di Raimondo, Francesco Di Raimondo, Paolo Vigneri, Paolo Vigneri   +24 more
doaj   +1 more source