Results 101 to 110 of about 184,218 (302)

High‐Resolution Genomic Characterization of WAGR Spectrum Disorder: Insights From a Novel Cohort and Literature Synthesis, and Validation of Patient‐Reported Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT WAGR spectrum disorder (WAGRSD) is an ultra‐rare congenital disorder caused by heterozygous deletion of chromosome 11p13. While classically associated with Wilms tumor, Aniridia, Genitourinary anomalies, and a Range of developmental delays, accurate delineation of the deletion is critical for prognosis because the phenotypic spectrum extends ...
Andrew M. George, Bamelak T. Duki, Zoe S. Katz, Aravind Viswanathan, Suzanne P. MacFarland, Evan R. Hathaway, Caitlin Monahan, John Morris, Kelly L. Trout, Shari M. Krantz, Arupa Ganguly, Jennifer M. Kalish   +11 more
wiley   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

An Investigation of the Role of Sex Difference in the Effect of Fluoxetine on Behavioral and Biochemical Changes in Male and Female Rats Exposed to Stress [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Unpredictable stressors cause changes in behavioral parameters such as motor and exploratory behaviors, feeding, and sexual and anxiety behaviors. Stress leads to the release of corticosteroids and, as a result, causes dysfunction
Moslem Mohammadi, Zahra Hosseini-Khah, Zhoobin Kalantari, Mehdi Jahandar, Forouzan Sadeghimahalli, Sakineh Shafia   +5 more
doaj  

Haloperidol’s Effect on the Expressions of TGFB, NT-3, and BDNF genes in Cultured Rat Microglia

Basic and Clinical Neuroscience, 2020
Introduction: Microglia, small glial cells, i.e. mesodermal in origin and found in the brain and spinal cord, play a key role in the maintenance of neurons and immune defense. Haloperidol, an antipsychotic drug, is used to treat numerous neurological and
Elham Namjoo, Mohammad Shekari, Aliyar Pirouzi, Hossein Forouzandeh, Davod Khalafkhany, Abdolvahid Vahedi, Iraj Ahmadi   +6 more
doaj  

Down-regulation of serotonergic genes expression in the raphe nuclei of midbrain under chronic social defeat stress in male mice [PDF]

, 2011
Background: There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety.
Maxim L. Filipenko, Natalia N. Kudryavtseva, Natalya P. Bondar, Ul’   +3 more
core   +1 more source

Sophisticated sperm allocation in male fowl [PDF]

, 2003
When a female is sexually promiscuous, the ejaculates of different males compete for the fertilization of her eggs; the more sperm a male inseminates into a female, the more likely he is to fertilize her eggs.
Pizzari, T., Cornwallis, C.K., Lovlie, H., Jakobssen, S., Birkhead, T.R.   +4 more
core   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training

Diabetes, Metabolic Syndrome and Obesity
Norbert Grzelak,1 Dominik Kaczmarek,2 Krystian Marek Poziemba,2 Włodzimierz Mrówczyński1 1Department of Neurobiology, Poznań University of Physical Education, Poznań, Poland; 2Department of Physiology and Biochemistry, Pozna ...
Grzelak N, Kaczmarek D, Poziemba KM, Mrówczyński W   +3 more
doaj  

FSD-C10, a Fasudil derivative, promotes neuroregeneration through indirect and direct mechanisms. [PDF]

, 2017
FSD-C10, a Fasudil derivative, was shown to reduce severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through the modulation of the immune response and induction of neuroprotective molecules in the ...
Chai, Zhi, Li, Xing, Li, Yan-Hua, Ma, Cun-Gen, Thome, Rodolfo, Wang, Qing, Xiao, Bao-Guo, Xie, Chong, Zhang, Guang-Xian, Zhang, Hai-Fei, Zhang, Yuan   +10 more
core   +2 more sources

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source