Results 81 to 90 of about 122,805 (310)

Regulatory Molecules of Synaptic Plasticity in Anxiety Disorder

International Journal of General Medicine, 2023
Zhongwei Sha, Jian Xu, Nana Li, Ou Li Department of Mental Diseases, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Zhongwei Sha ...
Sha Z, Xu J, Li N, Li O
doaj  

Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review [PDF]

, 2019
In most mature neurons, low levels of intracellular Cl− concentrations ([Cl−]i) are maintained by channels and transporters, particularly the K+-Cl- cotransporter 2 (KCC2), which is the only Cl− extruder in most neurons.
Sachiko Lee-Hotta, Lee-Hotta, Sachiko, Yasushi Uchiyama, Uchiyama, Yasushi, Satoshi Kametaka, Kametaka, Satoshi   +5 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Association of BDNF Val66Met Polymorphism and Brain BDNF levels with Major Depression and Suicide [PDF]

International Journal of Neuropsychopharmacology, 2017
ABSTRACT Brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of major depressive disorder (MDD) and suicide. Both are partly caused by early life adversity (ELA) and ELA reduces both BDNF protein and gene expression.
Youssef, Mariam M., Underwood, Mark D., Huang, Yung-Yu, Hsiung, Shu-chi, Liu, Yan, Simpson, Norman R., Bakalian, Mihran J., Rosoklija, Gorazd B., Dwork, Andrew J., Arango, Victoria, Mann, J. John   +10 more
openaire   +2 more sources

Relationship of BDNF SNP type and gender disparities in the STEM workforce

, 2021
Forbes, Chad E.The brain derived neurotrophic factor (BDNF) gene encodes for the BDNF protein that is essential for the development of the central nervous system.
Hadley, Lydia G.
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

BDNF-DT and BDNF-AS-DT : Novel Genes in the BDNF locus

Abstract Divergent transcription from bidirectional promoters is frequently observed in eukaryotic genomes, but the biological relevance of divergent RNA transcripts (DT) is unknown. We identified and characterized BDNF-DT , a novel DT gene, and BDNF-AS-DT
Svitlana V. Bach, Giovanna Punzi, Nuri E. Smith, Sreya Mukherjee, Joo Heon Shin, Qiang Chen, Geo Pertea, Leonardo Collado-Torres, Kristen R. Maynard, Stephanie C. Page, Joel E. Kleinman, Thomas M. Hyde, Daniel R. Weinberger, Keri Martinowich, Gianluca Ursini   +14 more
openaire   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Characteristics of the BDNF Val66Met polymorphism in competitive swimmers and judo athletes [PDF]

, 2020
Studies have demonstrated that motivation, aggression, excitation intensity, competitive spirit, and tolerance to psychological stress are included in major psychological factors affecting the performance of athletes.
Ohishi, Kenji, Asai, Taishi, Maeda, Hideki, Tanaka, Chikara, Abe, Daisuke, Takahashi, Yuusuke, Wada, Tadashi, Shinohara, Kazuyuki, Doi, Hirokazu, Nakahata, Yasukazu   +9 more
core  

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source