Results 111 to 120 of about 133,818 (257)

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

BDNF and TNF-alpha polymorphisms in memory

, 2013
Here, we investigate the genetic basis of human memory in healthy individuals and the potential role of two polymorphisms, previously implicated in memory function.
Lea, R. A., Haupt, L. M., McKenzie, K., Maher, B. H., Sutherland, H. G., Yogeetha, B. S., Okolicsyani, R. K., Griffiths, L. R., Griffiths, LR (reprint author), Griffith Univ, Genom Res Ctr, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia., Chan, R. C. K., Shum, D. H. K.   +10 more
core   +1 more source

Supplementary Material, Naha_Revised_Suppl_Cortex_final - Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#

, 2018
Supplementary Material, Naha_Revised_Suppl_Cortex_final for Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex# by Nibedita Naha, DN Gandhi, AK Gautam and J Ravi Prakash in Human
J Ravi Prakash (5099366), Nibedita Naha (5099363), DN Gandhi (5099357), AK Gautam (5099360)   +3 more
core   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

BDNF Levels and Cognitive Function in Patients with Type 2 Diabetes Treated with SGLT2 Inhibitors [PDF]

Objective: As cognitive impairment becoming more widely recognized as a complication of type 2 diabetes mellitus (T2DM), it is discussed in the literature that antihyperglycemic treatment may also improve cognitive functions.
Esra ÇALIŞICI, Betül SÜMBÜL ŞEKERCİ, Abdüsselam ŞEKERCİ, Şeymanur DEMİRHAN   +3 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice [PDF]

, 2008
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been ...
I. L. Kovalenko, Irina L. Kovalenko, U. A. Boyarskikh, M. L. Filipenko, Ul'yana A. Boyarskikh, N. N. Kudryavtseva, N. P. Bondar, Maxim L. Filipenko, Natalia P. Bondar, Natalia N. Kudryavtseva   +9 more
core  

Peripheral inflammatory markers and metabolic profiles in temporal lobe epilepsy and functional dissociative seizures

Epileptic Disorders, EarlyView.
Abstract Background Temporal lobe epilepsy (TLE) and functional dissociative seizures (FDS) are distinct conditions that share overlapping clinical, neuropsychiatric, and biological features, including depressive symptoms, obesity‐related metabolic dysregulation, and alterations in systemic inflammatory markers.
Betül Merd, Şeyma Benli, Fatmanur Merd, Meltem Sönmez, Füsun Ferda Erdoğan   +4 more
wiley   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

BDNF receptor cleavage : relevance for Alzheimer’s disease pathophysiology

, 2020
Alzheimer’s Disease (AD) is a chronic and progressive neurodegenerative disease, being the most common form of dementia worldwide (60-70% of all cases).
Fonseca-Gomes, João Filipe
core