Results 191 to 200 of about 220,963 (383)

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]

, 2019
Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis, Chan, C Savio, Chen, Yu, Day, Michelle, Guzman, Jaime N, Ilijic, Ema, Kaplitt, Michael, Kondapalli, Jyothisri, Kress, Geraldine J, Melendez, Alexandria E, Plotkin, Joshua L, Surmeier, D James, Wokosin, David L, Xie, Zhong   +13 more
core   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

Dopamine receptors and key elements of the neurotrophins (BDNF, CDNF) expression patterns during critical periods of ontogenesis in the brain structures of mice with autism-like behavior (BTBR) or its absence (С57BL/6J)

Вавиловский журнал генетики и селекции
Analysis of the mechanisms underlying autism spectrum disorder (ASD) is an urgent task due to the everincreasing prevalence of this condition. The study of critical periods of neuroontogenesis is of interest, since the manifestation of ASD is often ...
P. D. Pravikova, M. A. Arssan, E. A. Zalivina, E. M. Kondaurova, E. A. Kulikova, I. I. Belokopytova, V. S. Naumenko   +6 more
doaj   +1 more source

Research advances in dysphagia animal models

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai, Keling Cheng, Nannan Zhang, Yunfang Chen, Jun Ni, Zhiyong Wang   +5 more
wiley   +1 more source

Effects of Crocin on Brain Neurotrophins, Cognition, Balance and Pain in Toxic-Induced Demyelination Model

Acta Neurologica Taiwanica
Objective: The purpose of this study was to investigate the effects of Crocin on brain neuroterophins, cognition, sensory and motor dysfunction and compare to fingolimod effects in toxic-induced demyelination with Ethidium Bromide (EB) in female Wistar ...
Rouholah Fatemi, Hadi Fathi Moghaddam, Yaghoub Farbod, Roya Bigtashkhani   +3 more
doaj   +1 more source

Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation

Advanced NanoBiomed Research, EarlyView.
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos, Matteo Battaglini, Gianni Ciofani   +2 more
wiley   +1 more source

Neurotrophic Factors as Markers of Stroke Recovery: a Review

Вестник восстановительной медицины
INTRODUCTION. A review of studies on the role of neurotrophic factors: BDNF, NGF, BDNF, NGF, NT-3, NT-4/5, IGF-1 and other biomarkers, in predicting and enhancing ischemic stroke (IS) recovery is presented. AIM.
Elena V. Kostenko, Lyudmila V. Petrova, Pavel D. Egorov, Irene V. Pogonchenkova, Maxim S. Filippov   +4 more
doaj   +1 more source

BDNF regulates eating behavior and locomotor activity in mice [PDF]

, 2000
Steven G. Kernie
openalex   +1 more source

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, Accepted Article.
Controlling protein‐protein interactions is critical for dissecting signaling pathways, especially those initiated by ligand‐receptor interactions which alter receptor oligomerization and drive downstream signaling cascades. Traditional methods for driving protein‐protein complexes are using antibodies that face limitations in terms of stoichiometry ...
Johannes Broichhagen, Michael Trumpp, Blaise Gatin-Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau   +8 more
wiley   +1 more source

BDNF-Induced Potentiation of Spontaneous Twitching in Innervated Myocytes Requires Calcium Release From Intracellular Stores [PDF]

, 2000
Robin J. Kleiman, Ning Tian, David Križaj, Thomas N. Hwang, David R. Copenhagen, Louis F. Reichardt   +5 more
openalex   +1 more source