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Neuropharmacology, 2014
Fragile X syndrome (FXS) is a monogenic disorder that is caused by the absence of FMR1 protein (FMRP). FXS serves as an excellent model disorder for studies investigating disturbed molecular mechanisms and synapse function underlying cognitive impairment, autism, and behavioral disturbance. Abnormalities in dendritic spines and synaptic transmission in
Maija L, Castrén, Eero, Castrén
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Fragile X syndrome (FXS) is a monogenic disorder that is caused by the absence of FMR1 protein (FMRP). FXS serves as an excellent model disorder for studies investigating disturbed molecular mechanisms and synapse function underlying cognitive impairment, autism, and behavioral disturbance. Abnormalities in dendritic spines and synaptic transmission in
Maija L, Castrén, Eero, Castrén
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Bioinformatics Approach to BDNF and BDNF-Related Disorders
Current Neuropharmacology, 2011Context: Currently, the keyword 'BDNF' retrieves 7388 publications in Pubmed, which point to many directions.Objective: This paper aims to uncover patterns that are hidden under this huge mass of studies and then to review the most prominent sub-topics in 'BDNF and mental health'.Method: Several semi-automatic tools employed, in order to present: 1.
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MicroRNA function and neurotrophin BDNF
Neurochemistry International, 2011MicroRNAs (miRs), endogenous small RNAs, regulate gene expression through repression of translational activity after binding to target mRNAs. miRs are involved in various cellular processes including differentiation, metabolism, and apoptosis. Furthermore, possible involvement of miRs in neuronal function have been proposed.
Tadahiro, Numakawa +5 more
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Current Drug Research Reviews
Abstract: Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its main receptor, TrkB, are often diminished relative to controls, thereby serving as replacement therapy.
Robert Lalonde +2 more
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Abstract: Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its main receptor, TrkB, are often diminished relative to controls, thereby serving as replacement therapy.
Robert Lalonde +2 more
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2015
Rolandic epilepsy is considered to be the most common childhood epileptic syndrome. Different mutations in genes that control the excitability of neurons have been described. Recent reports on the involvement of the bdnf and elp4 genes in cell motility, migration, and adhesion make these genes candidate for Rolandic epilepsy susceptibility.
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Rolandic epilepsy is considered to be the most common childhood epileptic syndrome. Different mutations in genes that control the excitability of neurons have been described. Recent reports on the involvement of the bdnf and elp4 genes in cell motility, migration, and adhesion make these genes candidate for Rolandic epilepsy susceptibility.
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Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Nature Neuroscience, 2023Mykhailo Girych +2 more
exaly
2017
Blood plasma brain???derived neurotrophic factor (BDNF) levels were investigated in elderly and old patients with subcortical vascular mild cognitive disorders (SVMCD). Reduction of plasma BDNF levels correlated with some parameters of executive dysfunction, reflecting disorders of the link between the prefrontal cortex and subcortical structures due ...
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Blood plasma brain???derived neurotrophic factor (BDNF) levels were investigated in elderly and old patients with subcortical vascular mild cognitive disorders (SVMCD). Reduction of plasma BDNF levels correlated with some parameters of executive dysfunction, reflecting disorders of the link between the prefrontal cortex and subcortical structures due ...
openaire +1 more source