Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study. [PDF]
Bekkos CH+9 more
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Unlocking Alzheimer's Disease: The Role of BDNF Signaling in Neuropathology and Treatment. [PDF]
Alqahtani SM+8 more
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Altered Neuroplasticity in Epilepsy is Associated with Neuroinflammation and Oxidative Stress: In vivo Evidence of Brain-Derived Extracellular Vesicles. [PDF]
Wang S, Zhang H, Li R, Liu Z, Xiang D.
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Socioeconomic factors, brain-derived neurotrophic factor Val66Met polymorphism, and cortical structure in children and adolescents. [PDF]
Merz EC+7 more
europepmc +1 more source
High intensity interval training and selenium nanoparticles protect hippocampal neurons and enhance cognitive function in diabetic rats. [PDF]
Aliakbari K, Saidie P.
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To BDNF or Not to BDNF: That Is the Epileptic Hippocampus
The Neuroscientist, 2005Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has drawn much attention as a potential therapeutic target for temporal lobe epilepsy (TLE). TLE seizures are produced by synchronized hyperactivity of neuron populations due to the disruption of a balance between excitatory and inhibitory synaptic transmissions.
Ryuta Koyama, Yuji Ikegaya
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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Nature Neuroscience, 2008Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by ...
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NGF and BDNF in pediatrics syndromes
Neuroscience & Biobehavioral Reviews, 2023Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play multiple roles in different settings including neuronal development, function and survival in both the peripheral and the central nervous systems from early stages.
Ferraguti, Giampiero+9 more
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Brain-derived neurotrophic factor (BDNF) is a neurotrophin abundantly expressed in several areas of the central nervous system (CNS) and is known to induce a lasting potentiation of synaptic efficacy, to enhance specific learning and memory processes.
Pluchino N+5 more
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