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Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia
Behavioural Brain Research, 2020Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a critical role in the development of neurons.
Raghumoy Ghosh +5 more
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A role for BDNF in mechanosensation
Nature Neuroscience, 1998Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction.
Martin Koltzenburg +4 more
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BDNF dependence in neuroblastoma
Journal of Neuroscience Research, 2001AbstractNeuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied.
Hong Jiang +4 more
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2017
Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in ...
H Geoffroy, F Noble
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Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in ...
H Geoffroy, F Noble
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Bioinformatics Approach to BDNF and BDNF-Related Disorders
Current Neuropharmacology, 2011Context: Currently, the keyword 'BDNF' retrieves 7388 publications in Pubmed, which point to many directions.Objective: This paper aims to uncover patterns that are hidden under this huge mass of studies and then to review the most prominent sub-topics in 'BDNF and mental health'.Method: Several semi-automatic tools employed, in order to present: 1.
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Nature Neuroscience, 2000
To directly compare biological activities of the neurotrophins NT4 and BDNF in vivo, we replaced the BDNF coding sequence with the NT4 sequence in mice (Bdnfnt4-ki). Mice expressing NT4 in place of BDNF were viable, in contrast with BDNF null mutants, which die shortly after birth.
Guoping Fan +7 more
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To directly compare biological activities of the neurotrophins NT4 and BDNF in vivo, we replaced the BDNF coding sequence with the NT4 sequence in mice (Bdnfnt4-ki). Mice expressing NT4 in place of BDNF were viable, in contrast with BDNF null mutants, which die shortly after birth.
Guoping Fan +7 more
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Current Drug Research Reviews
Abstract: Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its main receptor, TrkB, are often diminished relative to controls, thereby serving as replacement therapy.
Robert Lalonde +2 more
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Abstract: Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its main receptor, TrkB, are often diminished relative to controls, thereby serving as replacement therapy.
Robert Lalonde +2 more
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Medical Hypotheses, 2008
(1) The hyperactivity hypothesis of BDNF in mania based on the observation that antidepressants that improve mood states can correspondingly upregulate BDNF levels in the brain, however, it has been proved that this is not the case for all antidepressants; for example, the SSRI antidepressant fluoxetine has either no effect [3] or decreases [4] BDNF ...
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(1) The hyperactivity hypothesis of BDNF in mania based on the observation that antidepressants that improve mood states can correspondingly upregulate BDNF levels in the brain, however, it has been proved that this is not the case for all antidepressants; for example, the SSRI antidepressant fluoxetine has either no effect [3] or decreases [4] BDNF ...
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The BDNF Val66Met polymorphism and smoking
Neuroscience Letters, 2008Although the brain derived neurotrophic factor (BDNF) has been mainly investigated in the context of depression and anxiety disorders, several studies also suggest an association between BDNF and smoking. BDNF represents a protein which crucially influences several processes in the cell ranging from growth to apoptosis. A functional variant of the BDNF
Martin Reuter +4 more
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BDNF in Anxiety and Depression
Science, 2006Adapting the social defeat paradigm developed by one of our groups ([1][1]), O. Berton and colleagues comprehensively evaluated the role of brain-derived neurotrophic factor (BDNF) in mouse social stress (“Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress,”
Allan V. Kalueff +3 more
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