Results 111 to 120 of about 999,841 (275)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Prosser-Type Sintered “Glassy” Beads Excavated from Dohouan (Côte d’Ivoire)

Ceramics
Recent archaeological sites dating to the late 19th and early 20th centuries have rarely been studied to date. Among the 500 “glassy” beads excavated from Dohouan (Côte d’Ivoire), elemental analyses reveal that fewer than half contain abnormally high ...
Kouakou Modeste Koffi, Philippe Colomban, Christophe Petit, Kouakou Siméon Kouassi   +3 more
doaj   +1 more source

Experimental evidence of solitary wave interaction in Hertzian chains

, 2011
We study experimentally the interaction between two solitary waves that approach one to another in a linear chain of spheres interacting via the Hertz potential.
Aude Caussarieu, E. Avalos, E. B. Herbold, Francisco Melo, Francisco Santibanez, L. D. Landau, M. Peyrard, P. G. Drazin, Romina Munoz, Stéphane Job, V. F. Nesterenko   +10 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Method for the use of polymer beads as dosimeters for low-energy electron irradiation

Frontiers in Physics
In this study, a novel bead-based dosimetry system was developed. This approach uses suspended polymethyl methacrylate beads, which experience a dose-dependent change in fluorescence intensities.
Joana Kira Besecke, Joana Kira Besecke, Joana Kira Besecke, Lysann Kenner, André Poremba, Jessy Schönfelder, Jessy Schönfelder, Tobias Teichmann, Martin Thoma, Martin Thoma, Thomas Grunwald, Thomas Grunwald, Elizabeth von Hauff, Elizabeth von Hauff, Ulla König, Björn Poppe, Simone Schopf, Simone Schopf   +17 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Microfluidic capturing-dynamics of paramagnetic bead suspensions

, 2005
We study theoretically the capturing of paramagnetic beads by a magnetic field gradient in a microfluidic channel treating the beads as a continuum. Bead motion is affected by both fluidic and magnetic forces.
Beenakker, Choi, Christian Mikkelsen, Dufresne, Gijs, Henrik Bruus, McCloskey, Mikkelsen, Pankhurst, Squires, Warnke, Zborowski   +11 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatū, New Zealand [PDF]

, 2017
Tuberculosis was in 1993 declared as a re-emerging disease by the World Health Organization. The only vaccine currently available, BCG, an attenuated strain of Mycobacterium bovis, does not protect adults against the pulmonary disease, which is the ...
Rubio Reyes, Patricia
core