Results 71 to 80 of about 5,346,014 (404)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Experimental research and numerical simulation of bearing capacity of high-steep rock foundations near slopes

矿业科学学报
This study conducted bearing capacity test of high-steep rock slope foundation under different slope angles and slope distances to investigate the bearing capacity of high-steep rock slope foundation.
LEI Yong, LIU Zikui, CHEN Yusi, HE Changjie, LI Jianxin   +4 more
doaj   +1 more source

Shallow grooves in journal improve air bearing performance [PDF]

, 1968
Bearing designs, which shape the surface to create artificial fluid-film wedges in the absence of any applied radial load, generate radial restoring forces to keep journals from whirling.
Anderson, W. J., Cunningham, R. E., Fleming, D. P.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of Ellipsoidal Modulus and Internal Pressure on Bearing Capacity of Thrust-Bearing Aft Dome

MATEC Web of Conferences, 2018
In order to analyse the effect of ellipsoidal modulus and internal pressure on bearing capacity of thrust-bearing aft dome, we obtain the stress and strain distribution and bearing capacity of 1.6, 1.4 and 1.0 modulus ellipsoidal aft dome under 0MPa~0 ...
Peng Wang, Ruixiang Fan, Cheng Huang, Dongyang Yan, Feifan Wang   +4 more
doaj   +1 more source

Undrained bearing capacity of spatially random soil for rectangular footings

Soils and Foundations, 2019
In this study, a new approach for the evaluation of the 3-D random bearing capacity in rectangular footings is described. The soil strength spatial variability is modelled by random fields.
M. Chwała
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

LONG BEARING CAPACITY OF WOODEN STRUCTURES

Structural Mechanics of Engineering Constructions and Buildings, 2014
In the work, the solution of a problem of stability of the compressed wooden elements with taking into account nonlinear creep of wood is presented.
A S Varenik, K A Varenik
doaj