Results 31 to 40 of about 106,966 (315)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Effect of ascorbic acid on reduced glutathione level in arsenic-loaded isolated liver tissues of rat

Bangladesh Journal of Pharmacology, 2006
Isolated liver tissues of rat were loaded with trivalent arsenic and were exposed in presence and absence of ascorbic acid. The amount of reduced glutathione (GSH) in normal liver tissue was 52.0  0.2 g/g protein.
Beauty Saha
doaj   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Perancangan Rangkaian Terpadu Penguat Operasional Untuk Pengatur Nada

Jurnal EECCIS (Electrics, Electronics, Communications, Controls, Informatics, Systems), 2012
Suatu rangkaian terpadu (integrated circuit -IC) adalah sebuah kristal silikon kecil yang disebut chip mengandung komponen elektronika seperti transistor,dioda, resistor, dan kapasitor. Komponen itu saling dihubungkan dalam chip membentuk suatu rangkaian
Beauty Beauty, Agung Darmawansyah, M. Julius Setyopranoto   +2 more
doaj   +1 more source

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

KONA Powder and Particle Journal, 2021
Microspheres composed of poly (lactic-co-glycolic acid) (PLGA) were formed in liquid droplets using the electrospray technique. The structure of the microspheres was controlled by changing the electric voltage of the electrospray.
Moe Tanaka, Ayaka Ochi, Aiko Sasai, Hiroyuki Tsujimoto, Hitomi Kobara, Hiromitsu Yamamoto, Akihiro Wakisaka   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management

Scientific Reports
Skin pigmentation disorders involve complex biological regulation, with tyrosinase (TYR) and melanocortin 1 receptor (MC1R) serving as key therapeutic targets.
Rongrong Deng, Shiqian Zheng, Shengjun Xie, Gengjiu Huang, Zhiwen Ou, Zhibin Shen   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Investigation of Patients’ Motivation for Cosmetic Surgery in a Nationwide Cosmetic Surgery Group

Plastic and Reconstructive Surgery, Global Open
Background:. Recently, cosmetic surgeons in Japan have used social media to advertise their procedures. We analyzed the influence of social and other media on patients’ motivation to visit our clinic using the aggregated results of a questionnaire ...
Yusuke Funakoshi, MD, PhD, Masao Saito, MD, PhD, Ko Kawaguchi, MD, Eri Hiramatsu, MD, Nobuo Yamamoto, MD, Yoshiko Hondo, MD, Yumiko Nakagawa, MD, PhD, Koki Okumura, MD, Asami Sato, MD, Hiroo Teranishi, MD   +9 more
doaj   +1 more source

Attitude to themselves and to the time perspective of women with cosmetic problems of their facial skin

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2023
Summary.  The central place in the system of personality relations is occupied by the attitude towards oneself. Its violations are the main link in the development of neurotic disorders and adaptation disorders.
E. S. Bagnenko
doaj   +1 more source