Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment [PDF]
Frontiers in ImmunologyThe significant identification of Beclin-1’s function in regulating autophagy flow signified a significant progression in our understanding of cellular operations.
Zhumin Cao +6 more
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Structural insights for selective disruption of Beclin 1 binding to Bcl-2 [PDF]
Communications Biology, 2023 Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain.
Yun-Zu Pan +4 more
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The elucidation of the dual role of Beclin-1 in ischemic stroke through systems biology modeling [PDF]
iScienceSummary: Beclin-1 plays a pivotal role in the interplay between autophagy and apoptosis in ischemic stroke, influencing both cell survival and death. We developed a mathematical model incorporating the dual role of Beclin-1 to simulate Beclin-1-induced ...
Jun Seok Cha +5 more
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Molecules, 2021 Expression levels of the major mammalian autophagy regulator Beclin 1 and its interaction with Bcl-2 regulate the switch between autophagic cell survival and apoptotic cell death pathways.
Miray Turk +5 more
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Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 [PDF]
BiologyAutophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles in neurodevelopment and maintenance. A crucial step in autophagy is the formation of the class III phosphatidylinositol 3-kinase complex 1 ...
Wai Wa Ray Chan +4 more
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Beclin-1–Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis
Frontiers in Cellular and Infection Microbiology, 2021 ObjectiveWe previously demonstrated that promoting Beclin-1–dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis.
Azadeh Nikouee +4 more
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The Role of Beclin 1-Dependent Autophagy in Cancer
Biology, 2019 Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or ...
Silvia Vega-Rubín-de-Celis
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Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
Frontiers in Cell and Developmental Biology, 2018 Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in double-membrane vesicles called autophagosomes.
Manoj B. Menon +2 more
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NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma
Molecular Oncology, 2020 NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high NEK2 confers inferior survival in multiple myeloma (MM); thus, a better understanding of the mechanisms by which NEK2 induces drug resistance in MM is ...
Jiliang Xia +18 more
doaj +2 more sources
Stress reduction through cortical bone thickening improves bone mechanical behavior in adult female Beclin-1+/− mice [PDF]
Frontiers in Bioengineering and BiotechnologyFragility fractures, which are more prevalent in women, may be significantly influenced by autophagy due to altered bone turnover. As an essential mediator of autophagy, Beclin-1 modulates bone homeostasis by regulating osteoclast and chondrocyte ...
Jiaojiao Yang +8 more
doaj +2 more sources